Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene.[5][6][7][8] Research suggests that the (human) enzyme participates in the conversion of phytol to phytanic acid in the peroxisomes, which is part of the process of breaking down phytol.[9] In particular, it catalyzes reactions of the form:
- a (2E)-enoyl-CoA + NADPH + H+
a 2,3-saturated acyl-CoA + NADP+
With affinity for trans-2-enoyl-CoAs of lengths between 4:1 and 16:1.[9]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000115425 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026189 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi:10.1074/jbc.M001168200. PMID 10811639.
- ↑ Amery L, Mannaerts GP, Subramani S, et al. (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID 11669066.
- ↑
- ↑ "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase".
- 1 2 Gloerich J, Ruiter JP, van den Brink DM, et al. (2006-04-03). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092-6. doi:10.1016/j.febslet.2006.03.011. PMID 16546181.
Further reading
- Gay F, Anglade I, Gong Z, et al. (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi:10.1210/mend.14.10.0538. PMID 11043578.
- Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
- Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC 113227. PMID 11937624.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
