Phorbol-diester hydrolase
| Phorbol-diester hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.51 | ||||||||
| CAS no. | 81181-74-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Phorbol-diester hydrolase (EC 3.1.1.51) is an enzyme that catalyzes the reaction
The enzyme characterised from murine liver hydrolyses the diterpenoid, phorbol 12,13-dibutyrate, to remove one specific butyrate ester, giving phorbol 13-butanoate and butyric acid. It also acts on 12-O-tetradecanoylphorbol-13-acetate.[1] Such phorbol diesters from croton oil are tumor promoters, so this reaction inactivates them.[2][3]
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.[4]
References
- ↑ Shoyab M, Warren TC, Todaro GJ (1981). "Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver". J. Biol. Chem. 256 (23): 12529–34. doi:10.1016/S0021-9258(18)43307-8. PMID 6946062.
- ↑ Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E (1983). "Phorbol ester receptors and the in vitro effects of tumor promoters". Annals of the New York Academy of Sciences. 407 (1): 303–315. Bibcode:1983NYASA.407..303B. doi:10.1111/j.1749-6632.1983.tb47836.x. PMID 6309054. S2CID 20089027.
- ↑ De Barros, Cândida R. M.; Ferreira, Luis M. M.; Nunes, Fernando M.; et al. (2011). "The potential of white-rot fungi to degrade phorbol esters of Jatropha curcas L. Seed cake". Engineering in Life Sciences. 11: 107–110. doi:10.1002/elsc.201000040.
- ↑ Enzyme 3.1.1.51 at KEGG Pathway Database.
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