Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.[5] It is mainly expressed in the oocytes and fertilized eggs in mice.[6][7]
Function
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors .[8]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000124374 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045896 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑
"Entrez Gene: Poly(A) binding protein interacting protein 2B". Retrieved 2018-05-10.
- ↑ Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N (September 2010). "The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice". The Journal of Clinical Investigation. 120 (9): 3389–3400. doi:10.1172/JCI43350. PMC 2929737. PMID 20739757.
- ↑ "Mouse Gene Paip2b". UCSC genome browser. UC Santa Cruz.
- ↑ Derry MC, Yanagiya A, Martineau Y, Sonenberg N (2006). "Regulation of poly(A)-binding protein through PABP-interacting proteins". Cold Spring Harbor Symposia on Quantitative Biology. 71: 537–543. doi:10.1101/sqb.2006.71.061. PMID 17381337.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
