Prolyl 3-hydroxylase 3

P3H3
Identifiers
Aliases	P3H3, GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3
External IDs	OMIM: 610342; MGI: 1315208; GeneCards: P3H3
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,839,847 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,857,752 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; anterior pituitary; ; right hemisphere of cerebellum; ; body of uterus; ; apex of heart; ; right ovary; ; ascending aorta; ; Descending thoracic aorta; ; left ovary; ; canal of the cervix;
	Top expressed in
	calvaria; ; saccule; ; external carotid artery; ; ascending aorta; ; aortic valve; ; internal carotid artery; ; vas deferens; ; dermis; ; neural layer of retina; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; L-ascorbic acid binding; dioxygenase activity; iron ion binding; oxidoreductase activity; metal ion binding; procollagen-proline 3-dioxygenase activity;
Cellular component	endoplasmic reticulum; catalytic complex;
Biological process	negative regulation of cell population proliferation; peptidyl-proline hydroxylation; collagen metabolic process; peptidyl-lysine hydroxylation; collagen biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10536
	14789
	ENSG00000110811
	ENSMUSG00000023191
	Q8IVL6
	Q8CG70
	NM_014262
	NM_013534
	NP_055077
	NP_038562
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl 3-hydroxylase 3 is an enzyme that in humans is encoded by the gene P3H3 (formally LEPREL2).^[5]^[6] As its name suggests, it acts as a collagen prolyl 3-hydroxylase.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000110811 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023191 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jarnum S, Kjellman C, Darabi A, Nilsson I, Edvardsen K, Aman P (Apr 2004). "LEPREL1, a novel ER and Golgi resident member of the Leprecan family". Biochem Biophys Res Commun. 317 (2): 342–51. doi:10.1016/j.bbrc.2004.03.060. PMID 15063763.
1 2 "Entrez Gene: LEPREL2 leprecan-like 2".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vranka JA, Sakai LY, Bächinger HP (2004). "Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes". J. Biol. Chem. 279 (22): 23615–21. doi:10.1074/jbc.M312807200. PMID 15044469.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000110811 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023191 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15063763-5] Jarnum S, Kjellman C, Darabi A, Nilsson I, Edvardsen K, Aman P (Apr 2004). "LEPREL1, a novel ER and Golgi resident member of the Leprecan family". Biochem Biophys Res Commun. 317 (2): 342–51. doi:10.1016/j.bbrc.2004.03.060. PMID 15063763.

[entrez-6] 1 2 "Entrez Gene: LEPREL2 leprecan-like 2".

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[6]

References

Further reading