Onyema Ogbuagu

Onyema Eberechukwu Ogbuagu (Listenⓘ; born June 20, 1978) is a US-born infectious diseases physician, educator, researcher, and clinical trial investigator, who was raised and educated in Nigeria. He is a professor of Medicine and Pharmacology at Yale School of Medicine in New Haven, CT, US and is the director of the Yale Antivirals and Vaccines Research Program, formerly the AIDS Program clinical trials unit.[1] His research contributions have focused on novel therapeutics and strategies for HIV/AIDS treatment and prevention as well as COVID-19 vaccination and treatment clinical trials.[2] He switched his focus at the beginning of the 2019 COVID pandemic and participated as a principal investigator (PI) on the Pfizer-BioNtech COVID-19 vaccine trials [3][4] and the Remdesivir SIMPLE trial[5] in 2020 and 2021. In pursuit of his global health component of his career, Ogbuagu also supports postgraduate physician medical education programs in low and middle income countries in sub-Saharan Africa in Rwanda (2013–2018) and Liberia (since 2017) as well as HIV treatment programs in Liberia (since 2018).

In his role as public health educator, he has worked to increase public understanding of mRNA vaccines.[6][7][8][9][10][11] Ogbuagu has also worked to decrease vaccine hesitancy.[12][13] He has been a co-author on 43 scholarly articles, according to the National Library of Medicine.[14] According to Google Scholar, one article he co-authored on Remdesivir and its use for Covid that appeared in JAMA was cited 504 times.[15] Ogbuagu was selected as the commencement speaker for Yale School of Medicine's class of 2021.[16]

Early life and education

Onyema Ogbuagu and an identical twin brother, Chibuzo Ogbuagu II, were born to Chibuzo and Stella Ogbuagu. Nigerian doctoral students attending Yale University and University of Pennsylvania, respectively, when their twins were born. The couple had graduated in the 1974 from the University of Nigeria, Nsukka, where Stella was valedictorian.[17] The family returned to Nigeria when Onyema and Chibuzo were five years old.

Before their recent retirement, Onyema's father was vice-chancellor of Abia State University, Nigeria, and his mother was a professor of sociology and a former deputy vice-chancellor of the same institution.[18]

Onyema Ogbuagu attended Auntie Margaret International Primary School in Calabar, and obtained his secondary education at Federal Government College, Okigwe, Imo State, Nigeria (1988 to1994), graduating at 15. He graduated from the College of Medical Sciences, University of Calabar, Nigeria in 2014. He completed his medical internship at the Ebonyi State University Teaching Hospital in Abakaliki, Nigeria. He then returned to the United States, where he interned at the Elmhurst campus of Icahn School of Medicine at Mount Sinai. Ogbuagu completed his residency and chief residency at Mount Sinai in 2010.[1]

Ogbuagu completed an infectious diseases fellowship at Yale School of Medicine in 2012 and assumed a faculty position as an assistant professor in the same year. Currently, he is an associate professor of medicine in the Department of Internal Medicine, Section of Infectious Diseases.[19]

Personal life

Ogbuagu is married to Grace Igiraneza Ogbuagu.[20][21] She is a nephrologist and member of the International Nephrology Society.[22]

Career

Ogbuagu is an HIV/AIDS physician and leads a clinical trials program at Yale that conducts research on infectious diseases. He has been the principal investigator on pharmacokinetic, phase 2 and 3 safety and efficacy trials of novel antiviral compounds for HIV in addition to his recent work on COVID-19 vaccinations and therapeutics.[23]

He is a clinician at Yale Medicine, the medical practice of Yale School of Medicine, and sees patients at Yale New Haven Hospital's Nathan Smith Clinic.[24]

Ogbuagu trains physicians in Liberia and Rwanda. He has been a visiting professor to the National University of Rwanda since 2012, where he mentors medical residents and junior faculty and assists them in conducting clinical research projects that have local importance such as HIV/AIDS and antimicrobial resistance. In Liberia, he is program director of Yale's Office of Global Health's efforts to support Internal Medicine residency training. He trained the first infectious disease fellow in Liberia.[25]

COVID-19 and HIV/AIDS research

At the beginning of the COVID-19 pandemic, Ogbuagu shifted his focus from AIDS/HIV research and patient care to lead vaccine trials for COVID-19 at the Yale Center for Clinical Investigation where he was a PI on the Pfizer-BioNtech COVID-19 mRNA vaccine trial arms at Yale in adults as well as the pediatric studies for12-15 year-olds and 6 month to 11 year olds. The adult Pfizer BioNtech vaccine received emergency use authorization in the United States from the Food and Drug Administration (FDA) in 2020 and full FDA approval in 2021. There were approximately 150 sites for the Pfizer BioNtech mRNA trial, each led by a principal investigator.

Ogbuagu was also a PI for the second Phase 2b Sanofi-Glaxo Smith Klein novel COVID-19 vaccination candidate. He was also the Yale site PI for COVID treatment studies including the Remdesivir SIMPLE moderate and Severe trials.[26]

Previous to this clinical trial work, he researched pharmacokinetic, phase 2 and 3 safety and efficacy trials of novel antiviral compounds (HIV), and conducted HIV prevention trials.[1][27]

Awards

In 2015, Ogbuagu was elected as a Fellow of the American College of Physicians. In 2017, He received the Steve Huot Faculty Award for Dedication and Excellence from Yale School of Medicine's  Internal Medicine Primary Care Program.

In 2014 and in 2019, he received the Gerald H. Friedland prize for outstanding international research presentation by the Connecticut Infectious Diseases Society. On February 18, 2020, he also received an award from the Rwanda College of Physicians for his contribution in the fight against infectious diseases.

Ogbuagu received the annual innovator award of the HIV Medical Association at IDWeek 2024 conference in Los Angeles, California.

Publications

References

  1. 1 2 3 "Onyema Ogbuagu, MBBCh, FACP, FIDSA". medicine.yale.edu. Retrieved 2021-06-17.
  2. ↑ Sopeyin, Anuoluwapo; Hornsey, Emilio; Okwor, Tochi; Alimi, Yewande; Raji, Tajudeen; Mohammed, Abdulaziz; Moges, Hiwot; Onwuekwe, Ezinne V C.; Minja, Frank J.; Gon, Giorgia; Ogbuagu, Onyema; Ogunsola, Folasade; Paintsil, Elijah (2020). "Transmission risk of respiratory viruses in natural and mechanical ventilation environments: Implications for SARS-CoV-2 transmission in Africa". BMJ Global Health. 5 (8) e003522. doi:10.1136/bmjgh-2020-003522. PMC 7462043. PMID 32863269.
  3. ↑ Frenck, Robert W.; Klein, Nicola P.; Kitchin, Nicholas; Gurtman, Alejandra; Absalon, Judith; Lockhart, Stephen; Perez, John L.; Walter, Emmanuel B.; Senders, Shelly; Bailey, Ruth; Swanson, Kena A. (2021-07-15). "Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents". The New England Journal of Medicine. 385 (3): 239–250. doi:10.1056/NEJMoa2107456. ISSN 1533-4406. PMC 8174030. PMID 34043894.
  4. ↑ Polack, Fernando P.; Thomas, Stephen J.; Kitchin, Nicholas; Absalon, Judith; Gurtman, Alejandra; Lockhart, Stephen; Perez, John L.; Pérez Marc, Gonzalo; Moreira, Edson D.; Zerbini, Cristiano; Bailey, Ruth (2020-12-31). "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine". The New England Journal of Medicine. 383 (27): 2603–2615. doi:10.1056/NEJMoa2034577. ISSN 1533-4406. PMC 7745181. PMID 33301246.
  5. ↑ Spinner, Christoph D.; Gottlieb, Robert L.; Criner, Gerard J.; Arribas López, José Ramón; Cattelan, Anna Maria; Soriano Viladomiu, Alex; Ogbuagu, Onyema; Malhotra, Prashant; Mullane, Kathleen M.; Castagna, Antonella; Chai, Louis Yi Ann (2020-09-15). "Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial". JAMA. 324 (11): 1048–1057. doi:10.1001/jama.2020.16349. hdl:1887/3185309. ISSN 0098-7484. PMC 7442954. PMID 32821939.
  6. ↑ Julia Hollingsworth, Adam Renton, Emma Reynolds, Nada Bashir, Melissa Macaya and Meg Wagner (2020-12-10). "Pfizer principal investigator "very optimistic" about positive news after FDA meeting". CNN. Retrieved 2021-06-17.{{cite web}}: CS1 maint: multiple names: authors list (link)
  7. ↑ "Video: What you need to know about COVID-19 vaccine distribution". ABC News. Retrieved 2021-06-17.
  8. ↑ "Low public trust could hurt vaccine distribution in minority communities". MSNBC.com. Retrieved 2021-06-17.
  9. ↑ New Pfizer trial shows vaccine 100% effective in teens 12-15, retrieved 2021-06-17
  10. ↑ Johnson, Carolyn Y. (27 August 2020). "Large U.S. covid-19 vaccine trials are halfway enrolled, but lag on participant diversity". Washington Post. Retrieved 2021-06-17.
  11. ↑ "Connecticut's Shot in the Arm: State leaders, health officials discuss COVID-19 vaccine". WTNH.com. 2020-12-02. Retrieved 2021-08-30.
  12. ↑ "T.D. Jakes Hosts Conversation with COVID-19 Vaccine Scientists". www.prnewswire.com (Press release). Retrieved 2021-06-17.
  13. ↑ "COVID Vaccines and the Return to Life: Part 1". The Aspen Institute. Retrieved 2021-07-02.
  14. ↑ "Onyema Ogbuagu - Search Results - PubMed". PubMed. Retrieved 2021-06-23.
  15. ↑ Spinner, Christoph D.; Gottlieb, Robert L.; Criner, Gerard J.; Arribas López, José Ramón; Cattelan, Anna Maria; Soriano Viladomiu, Alex; Ogbuagu, Onyema; Malhotra, Prashant; Mullane, Kathleen M.; Castagna, Antonella; Chai, Louis Yi Ann (2020-09-15). "Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial". JAMA. 324 (11): 1048–1057. doi:10.1001/jama.2020.16349. hdl:1887/3185309. ISSN 0098-7484. PMC 7442954. PMID 32821939.
  16. ↑ "MD Class of 2021 Selects Associate Professor Onyema Ogbuagu as Commencement Speaker". medicine.yale.edu. Archived from the original on 2021-06-16. Retrieved 2021-06-17.
  17. ↑ "Meet Onyema Ogbuagu, di Nigerian inside Pfizer Covid-19 vaccine breakthrough". BBC News Pidgin. Retrieved 2021-06-17.
  18. ↑ "PROFILE: Meet Onyema Ogbuagu, UNICAL graduate leading COVID-19 vaccine research in US". TheCable. 2020-11-22. Retrieved 2022-02-02.
  19. ↑ Barakat, Lydia Aoun; Dunne, Dana W.; Tetrault, Jeanette M.; Soares, Sarita; Chia, David; Ogbuagu, Onyema E.; Moriarty, John P.; Huot, Stephen J.; Green, Michael L. (November 2018). "The Changing Face of HIV Care: Expanding HIV Training in an Internal Medicine Residency Program". Academic Medicine: Journal of the Association of American Medical Colleges. 93 (11): 1673–1678. doi:10.1097/ACM.0000000000002317. ISSN 1938-808X. PMID 29901657. S2CID 49191395.
  20. ↑ "Yale physician, daughter share message about COVID vaccination as pediatric hospitalizations surge". WTNH.com. 2022-01-08. Retrieved 2022-02-03.
  21. ↑ Lucci-Canapari, Jeanna. "Vaccine Clinic Offers Choice and Reassurance to New Haven Children". medicine.yale.edu. Archived from the original on 2022-02-03. Retrieved 2022-02-03.
  22. ↑ Parmar, Reema (2020-05-12). "Research by Young ISN Members Highlights the Importance of Sub-tertiary Hospital Capacity to Manage Kidney Disease in Low- and Middle-income Countries". International Society of Nephrology. Retrieved 2022-02-03.
  23. ↑ Horowitch, Rose (2020-04-06). "Yale investigates potential treatments for COVID-19". Yale Daily News. Retrieved 2021-06-17.
  24. ↑ "Onyema E. Ogbuagu, MD Infectious Disease of Yale New Haven Hospital". www.ynhh.org. Retrieved 2022-02-02.
  25. ↑ "Onyema Ogbuagu". Yale Medicine. Retrieved 2021-06-17.
  26. ↑ Spinner, Christoph D.; Gottlieb, Robert L.; Criner, Gerard J.; Arribas López, José Ramón; Cattelan, Anna Maria; Soriano Viladomiu, Alex; Ogbuagu, Onyema; Malhotra, Prashant; Mullane, Kathleen M.; Castagna, Antonella; Chai, Louis Yi Ann (2020-09-15). "Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial". JAMA. 324 (11): 1048–1057. doi:10.1001/jama.2020.16349. ISSN 1538-3598. PMC 7442954. PMID 32821939.
  27. ↑ Nneji, Bernard (April 29, 2021). "COVID-19 Clinical Trials for Treatment and Prevention - Learning from Successes". Columbia Alumni Association of Fairfield County. Retrieved 2022-02-02.
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