Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a protein that in humans is encoded by the OVGP1 gene.[5][6][7]
Function
Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[7]
Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [8]
OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure.[9]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000085465 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074340 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Arias EB, Verhage HG, Jaffe RC (February 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biology of Reproduction. 51 (4): 685–694. doi:10.1095/biolreprod51.4.685. PMID 7819450.
- ↑ Lapensee L, Paquette Y, Bleau G (November 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertility and Sterility. 68 (4): 702–708. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
- 1 2 "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
- ↑ Laheri S, Modi D, Bhatt P (March 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. S2CID 10274575.
- ↑ Laheri S, Ashary N, Bhatt P, Modi D (August 2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.
Further reading
- Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology. 122 (4): 1639–1645. doi:10.1210/endo-122-4-1639. PMID 3278893.
- Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". Journal of Dental Research. 76 (3): 734–743. doi:10.1177/00220345970760030501. PMID 9109822. S2CID 39525421.
- Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". Journal of Dental Research. 79 (2): 732–739. doi:10.1177/00220345000790020601. PMID 10728974. S2CID 27558675.
- Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Molecular Human Reproduction. 8 (2): 167–175. doi:10.1093/molehr/8.2.167. PMID 11818519.
- Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle". Journal of Assisted Reproduction and Genetics. 19 (12): 569–576. doi:10.1023/A:1021263132176. PMC 3455833. PMID 12503889.
- Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas. 139 (1): 75–79. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.
- Woo MM, Alkushi A, Verhage HG, Magliocco AM, Leung PC, Gilks CB, et al. (December 2004). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clinical Cancer Research. 10 (23): 7958–7964. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.
- Ling L, Lee YL, Lee KF, Tsao SW, Yeung WS, Kan FW (October 2005). "Expression of human oviductin in an immortalized human oviductal cell line". Fertility and Sterility. 84 Suppl 2 (Suppl 2): 1095–1103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.
- Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Molecular Human Reproduction. 12 (4): 275–282. doi:10.1093/molehr/gal028. PMID 16567366.
