OTUD1

OTUD1
Identifiers
AliasesOTUD1, DUBA7, OTDC1, OTU deubiquitinase 1
External IDsOMIM: 612022; MGI: 1918448; GeneCards: OTUD1
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
3.4.19.12↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

220213

71198

Ensembl

ENSG00000165312

ENSMUSG00000043415

UniProt

Q5VV17

Q9CUB6

RefSeq (mRNA)

NM_001145373

NM_027715

RefSeq (protein)

NP_001138845

NP_081991

Location (UCSC)Chr 10: 23.44 – 23.44 MbChr 2: 19.66 – 19.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OTU deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene.[5]

Function

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165312 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043415 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: OTU deubiquitinase 1". Retrieved 2016-03-13.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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