O-phosphoserine sulfhydrylase
| O-phosphoserine sulfhydrylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.65 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
O-phosphoserine sulfhydrylase (EC 2.5.1.65) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme characterised from Aeropyrum pernix are phosphoserine and hydrogen sulfide (H2S). Its products are cysteine and orthophosphate (Pi). The enzyme can also use O-acetylserine as a source of the 2-amino-2-carboxyethyl group that is transferred, giving acetic acid as a byproduct.[1][2][3]
This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase. This enzyme is also called O-phosphoserine(thiol)-lyase.[4]
See also
- Cysteine synthase, which produces cysteine from O-acetylserine but not phosphoserine
References
- ↑ Mino K, Ishikawa K (2003). "A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1". FEBS Lett. 551 (1–3): 133–8. Bibcode:2003FEBSL.551..133M. doi:10.1016/S0014-5793(03)00913-X. PMID 12965218.
- ↑ Mino K, Ishikawa K (2003). "Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1". J. Bacteriol. 185 (7): 2277–84. doi:10.1128/JB.185.7.2277-2284.2003. PMC 151494. PMID 12644499.
- ↑ Mino K, Oda Y, Ataka M, Ishikawa K (2003). "Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1". Acta Crystallogr. D. 59 (Pt 2): 338–40. doi:10.1107/S0907444902017900. PMID 12554945.
- ↑ Enzyme 2.5.1.65 at KEGG Pathway Database.