Nocardicin-A epimerase
| Nocardicin-A epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.1.1.14 | ||||||||
| CAS no. | 118246-75-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Nocardicin-A epimerase (EC 5.1.1.14) is an enzyme that catalyzes two related chemical reactions in the biosynthetic sequence to nocardicin A in Nocardia uniformis. Its effect is to invert the stereochemistry of the amino acid sidechain in the substrate, isonocardicin C, to give its epimer, nocardicin C.[1][2][3]
isonocardicin C
nocardicin C
The enzyme can alternatively form the eimer of an oxime derivative of isonocardicin C (isonocardicin A), which produces nocardicin A.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is nocardicin-A epimerase. This enzyme is also called isonocardicin A epimerase.[4]
References
- ↑ Wilson, Brenda A.; Bantia, Shanta.; Salituro, Gino M.; Reeve, Anne M.; Townsend, Craig A. (1988). "Cell-free biosynthesis of nocardicin a from nocardicin e and S-adenosylmethionine". Journal of the American Chemical Society. 110 (24): 8238–8239. doi:10.1021/ja00232a047.
- ↑ Kelly, Wendy L.; Townsend, Craig A. (2004). "Mutational Analysis and Characterization of Nocardicin C-9′ Epimerase". Journal of Biological Chemistry. 279 (37): 38220–38227. doi:10.1074/jbc.M405450200. PMID 15252031.
- ↑ Kelly, Wendy L.; Townsend, Craig A. (2005). "Mutational Analysis of nocK and nocL in the Nocardicin a Producer Nocardia uniformis". Journal of Bacteriology. 187 (2): 739–746. doi:10.1128/JB.187.2.739-746.2005. PMC 543527. PMID 15629944.
- ↑ Enzyme 5.1.1.14 at KEGG Pathway Database.
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