Nibrozetone

Nibrozetone
Clinical data
Other namesRrx-001
Identifiers
  • 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC5H6BrN3O5
Molar mass268.023 g·mol−1
3D model (JSmol)
  • C1C(CN1C(=O)CBr)([N+](=O)[O-])[N+](=O)[O-]
  • InChI=InChI=1S/C5H6BrN3O5/c6-1-4(10)7-2-5(3-7,8(11)12)9(13)14/h1-3H2
  • Key:JODKFOVZURLVTG-UHFFFAOYSA-N

Nibrozetone is an investigational new drug that is being evaluated by EpicentRx for the treatment of oral mucositis in head and neck cancer patients. It is a small molecule that combines direct inhibition of the NLRP3 inflammasome, induction of NRF2, and release of nitric oxide under hypoxic conditions.[1][2] It has received Fast Track designation from the FDA for severe oral mucositis in head and neck cancer patients.[3]

References

  1. ↑ Oronsky B, Takahashi L, Gordon R, Cabrales P, Caroen S, Reid T (2023). "RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist". Frontiers in Oncology. 13 1204143. doi:10.3389/fonc.2023.1204143. PMC 10258348. PMID 37313460.
  2. ↑ Jayabalan N, Oronsky B, Cabrales P, Reid T, Caroen S, Johnson AM, et al. (April 2023). "A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation". Drugs. 83 (5): 389–402. doi:10.1007/s40265-023-01838-z. PMC 10015535. PMID 36920652.
  3. ↑ Ryan C (30 March 2023). "FDA Grants Fast Track Designation to RRx-001 for Severe Oral Mucositis in Head and Neck Cancer". OncLive.


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