Nadine Provençal

Nadine Provençal
AwardsCIFAR Global Scholars, Canadian Institute for Advanced Research, 2020 and 2026.

Canadian Institutes of Health Research Fellowship, 2015–2017.

Richard Todd Award, International Society of Psychiatric Genetics, 2014.
Academic background
EducationBSc, Biology, 2004, Université Laval
PhD, Pharmacology and Therapeutics (Epigenetics), 2013, McGill University
Alma materMcGill University
Thesis (2013)
Academic work
DisciplineEpigenetic, stress, mental health
InstitutionsSimon Fraser University
Websitehttps://www.sfu.ca/fhs/about/people/profiles/nadine-provencal.html

Nadine Provençal is a Canadian researcher in health sciences whose academic path has focused on biology, epigenetics, early life adversity, and developmental trajectories of health and disease. Her research focuses on epigenetics of anxiety and stress-related disorder She is an assistant professor at Simon Fraser University and worked as an Investigator at BC Children's Hospital Research Institute. In 2020, she was recognized by the Canadian Institute for Advanced Research (CIFAR) with an appointment to CIFAR Global Scholar.

Early life and education

Provençal earned a Bachelor of Science degree in Biology, with a focus on genetics and molecular and cellular biology, from Université Laval.[1] She then pursued doctoral studies at McGill University in Pharmacology and Therapeutics, specializing in epigenetics. Her PhD research examined the epigenetics of early life adversity and aggression in children[2] and macaques.[3] She completed the degree in 2013 in collaboration with the Research Unit on Children's Psychosocial Maladjustment (GRIP) in Montréal.

Provençal continued her training through postdoctoral work at the Université de Montréal, where she further developed her research on epigenetics and child behaviour.[4] She later received a Canadian Institutes of Health Research fellowship to undertake additional postdoctoral training at the Max Planck Institute of Psychiatry in Germany, focusing on epigenetic mechanisms involved in our response to stress and psychiatric disorders[5] using a neuronal cellular model and longitudinal cohorts.[6]

Career

In 2017, Provençal was recruited for a joint appointment at Simon Fraser University faculty of Health Sciences. She also serves as an Investigator at BC Children's Hospital Research Institute and remains connected to the Max Planck Institute of Psychiatry as a Guest Research Scientist. She received $450,000 through the Canada Foundation for Innovation John R. Evans Leaders Fund to open and lead the Epigenomics of Developmental Trajectories laboratory, which would include sequencing platform capable of analyzing the entire genome of multiple individuals.[7]

Across these roles, she has built a research program that connects molecular biology with urgent questions in child health and mental health.[8] Her work combines knowledge from multiple field of study including molecular biology, epigenomics, bioinformatics, psychology and psychiatry with cellular and animal models, as well as human cohort to study these complexes behaviours and disorders.[9][10][11][12][13][14]

Provençal received the Richard Todd Award from the International Society of Psychiatric Genetics in 2014, recognizing her research contribution to the genetics of child psychiatry. In 2020, Provençal was recognized by the Canadian Institute for Advanced Research (CIFAR) with an appointment to CIFAR Azrieli Global Scholar.[15]

Research Contributions

Provençal's central contribution is to developmental epigenetics: the study of how environmental exposures can influence gene regulation without changing the underlying DNA sequence. Her work focuses on the biological embedding of early life adversity, exploring how stress, trauma, caregiving environments, and other early experiences may leave molecular signatures that affect brain development, stress regulation, behaviour, and long-term health.

Her studies have examined DNA methylation patterns associated with maternal rearing, childhood physical aggression, glucocorticoid exposure, and stress-related psychiatric risk. By combining evidence from animal models, cellular systems, and longitudinal human cohorts, her work bridges basic molecular science and population health, helping to explain how early adversity can become linked to later vulnerability—or, in some cases, resilience.

The broader promise of Provençal's research lies in its translational reach. By identifying biological pathways associated with early experience, her work may inform prevention, early intervention, and future therapeutic strategies aimed at improving child health and reducing the long-term burden of stress-related disorders.

Selected Publications from Provençal's team

  • Barr, E., Comtois-Cabana, M., Coope, A., Côté, S. M., Kobor, M. S., Konwar, C., Lupien, S., Geoffroy, M.-C., Boivin, M., Provençal, N., Catherine, N. L. A., Dennis, J. K., & Ouellet-Morin, I. (2025). Early-life adversity and epigenetic aging: Findings from a 17-year longitudinal study. Biomolecules, 15(6), 887. https://doi.org/10.3390/biom15060887
  • Arcego, D. M., Buschdorf, J. P., O'Toole, N., Wang, Z., Barth, B., Pokhvisneva, I., Rayan, N. A., Patel, S., de Mendonça Filho, E. J., Lee, P., Tan, J., Koh, M. X., Sim, C. M., Parent, C., de Lima, R. M. S., Clappison, A., O'Donnell, K. J., Dalmaz, C., Arloth, J., Provençal, N., Binder, E. B., Diorio, J., Silveira, P. P., & Meaney, M. J. (2024). A glucocorticoid-sensitive hippocampal gene network moderates the impact of early-life adversity on mental health outcomes. Biological Psychiatry, 95(1), 48–61. https://doi.org/10.1016/j.biopsych.2023.06.028
  • Provençal, N., Arloth, J., Cattaneo, A., Anacker, C., Cattane, N., Wiechmann, T., Röh, S., Ködel, M., Klengel, T., Czamara, D., Müller, N. S., Lahti, J., Räikkönen, K., Pariante, C. M., & Binder, E. B. (2020). Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. Proceedings of the National Academy of Sciences, 117(38), 23280–23285. https://doi.org/10.1073/pnas.1820842116
  • Provençal, N., & Binder, E. B. (2015). The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, 268, 10–20. https://doi.org/10.1016/j.expneurol.2014.09.001
  • Provençal, N., Suderman, M. J., Guillemin, C., Massart, R., Ruggiero, A., Wang, D., Bennett, A. J., Pierre, P. J., Friedman, D. P., Côté, S. M., Hallett, M., Tremblay, R. E., Suomi, S. J., & Szyf, M. (2012). The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. Journal of Neuroscience, 32(44), 15626–15642. https://doi.org/10.1523/JNEUROSCI.1470-12.2012

References

  1. ↑ Provençal, Nadine; Shink, Eric; Harvey, Mario; Tremblay, Monique; Barden, Nicholas (December 2004). "Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 28 (8): 1299–1303. doi:10.1016/j.pnpbp.2004.07.001. PMID 15588756.
  2. ↑ Provençal, Nadine; Booij, Linda; Tremblay, Richard E. (2015-01-01). Hoppeler, Hans H. (ed.). "The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity". Journal of Experimental Biology. 218 (1): 123–133. Bibcode:2015JExpB.218..123P. doi:10.1242/jeb.111401. ISSN 1477-9145. PMID 25568459.
  3. ↑ Provençal, Nadine; Suderman, Matthew J.; Guillemin, Claire; Massart, Renaud; Ruggiero, Angela; Wang, Dongsha; Bennett, Allyson J.; Pierre, Peter J.; Friedman, David P.; Côté, Sylvana M.; Hallett, Michael; Tremblay, Richard E.; Suomi, Stephen J.; Szyf, Moshe (2012-10-31). "The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells". The Journal of Neuroscience. 32 (44): 15626–15642. doi:10.1523/JNEUROSCI.1470-12.2012. ISSN 0270-6474. PMC 3490439. PMID 23115197.
  4. ↑ Provençal, Nadine; Booij, Linda; Tremblay, Richard E. (2015-01-01). Hoppeler, Hans H. (ed.). "The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity". Journal of Experimental Biology. 218 (1): 123–133. Bibcode:2015JExpB.218..123P. doi:10.1242/jeb.111401. ISSN 1477-9145. PMID 25568459.
  5. ↑ Schlee, Anke (October 9, 2015). "Canadian Institute for Health Research fellowship: Epigenetic effects in stress-related disorders". psych.mpg.de. Retrieved August 16, 2020.
  6. ↑ Provençal, Nadine; Arloth, Janine; Cattaneo, Annamaria; Anacker, Christoph; Cattane, Nadia; Wiechmann, Tobias; Röh, Simone; Ködel, Maik; Klengel, Torsten; Czamara, Darina; Müller, Nikola S.; Lahti, Jari; PREDO team; Räikkönen, Katri; Pariante, Carmine M. (2020-09-22). "Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation". Proceedings of the National Academy of Sciences. 117 (38): 23280–23285. Bibcode:2020PNAS..11723280P. doi:10.1073/pnas.1820842116. ISSN 0027-8424. PMC 7519233. PMID 31399550.
  7. ↑ "Nadine Provençal, au cœur du génome". thelasource.com (in French). June 12, 2018. Retrieved August 16, 2020.
  8. ↑ "New eBrain Centre, 'Homeware' Lab to be created at SFU Surrey campus". sfu.ca. April 11, 2018. Retrieved August 15, 2020.
  9. ↑ Dick, Alec; Provencal, Nadine (2018), "Central Neuroepigenetic Regulation of the Hypothalamic–Pituitary–Adrenal Axis", Progress in Molecular Biology and Translational Science, vol. 158, Elsevier, pp. 105–127, doi:10.1016/bs.pmbts.2018.04.006, ISBN 978-0-12-812592-2, PMID 30072050, retrieved 2026-07-14
  10. ↑ Hack, Laura M.; Dick, Alec L.W.; Provençal, Nadine (August 2016). "Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1". Environmental Epigenetics. 2 (3) dvw016. doi:10.1093/eep/dvw016. ISSN 2058-5888. PMC 5804530. PMID 29492296.
  11. ↑ Zannas, Anthony S.; Provençal, Nadine; Binder, Elisabeth B. (September 2015). "Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions". Biological Psychiatry. 78 (5): 327–335. doi:10.1016/j.biopsych.2015.04.003. PMID 25979620.
  12. ↑ Provençal, Nadine; Binder, Elisabeth B. (June 2015). "The effects of early life stress on the epigenome: From the womb to adulthood and even before". Experimental Neurology. 268: 10–20. doi:10.1016/j.expneurol.2014.09.001. PMID 25218020.
  13. ↑ Provencal, Nadine; Binder, Elisabeth B (February 2015). "The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics". Current Opinion in Neurobiology. 30: 31–37. doi:10.1016/j.conb.2014.08.007. PMID 25218938.
  14. ↑ Provençal, Nadine; Booij, Linda; Tremblay, Richard E. (2015-01-01). Hoppeler, Hans H. (ed.). "The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity". Journal of Experimental Biology. 218 (1): 123–133. Bibcode:2015JExpB.218..123P. doi:10.1242/jeb.111401. ISSN 1477-9145. PMID 25568459.
  15. ↑ "Newly named global scholar to study "how stress gets under skin" of children". sfu.ca. August 12, 2020. Retrieved August 16, 2020.
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