NUDT5

NUDT5
Identifiers
Aliases	NUDT5, YSA1, YSA1H, YSAH1, hYSAH1, nudix hydrolase 5, hNUDT5
External IDs	OMIM: 609230; MGI: 1858232; GeneCards: NUDT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DSB, 2DSC, 2DSD, 3AC9, 3ACA, 3BM4, 3L85
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	12,196,144 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	5,871,895 bp
RNA expression pattern
	Top expressed in
	gonad; ; right lobe of liver; ; ganglionic eminence; ; rectum; ; stromal cell of endometrium; ; gingival epithelium; ; islet of Langerhans; ; mucosa of ileum; ; ventricular zone; ; anterior pituitary;
	Top expressed in
	otic placode; ; gastrula; ; embryo; ; epiblast; ; embryo; ; primary oocyte; ; primitive streak; ; abdominal wall; ; medullary collecting duct; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; hydrolase activity; magnesium ion binding; metal ion binding; nucleoside-diphosphatase activity; RNA binding; ADP-sugar diphosphatase activity; snoRNA binding; 8-oxo-dGDP phosphatase activity; protein binding; transferase activity; ADP-ribose diphosphatase activity; protein homodimerization activity; nucleotidyltransferase activity;
Cellular component	cytosol; extracellular exosome; intracellular anatomical structure; nucleus;
Biological process	nucleobase-containing small molecule catabolic process; ribonucleoside diphosphate catabolic process; nucleobase-containing compound metabolic process; nucleotide metabolic process; D-ribose catabolic process; chromatin remodeling; ATP generation from poly-ADP-D-ribose; nucleoside phosphate metabolic process; ribose phosphate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11164
	53893
	ENSG00000165609
	ENSMUSG00000025817
	Q9UKK9
	Q9JKX6
	NM_014142; NM_001321647; NM_001321648
	NM_016918
	NP_001308576; NP_001308577; NP_054861
	NP_058614
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.^[5]^[6]

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165609 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025817 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol Med. 4 (1): 79–89. doi:10.3892/ijmm.4.1.79. PMID 10373642.
1 2 "Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5".

Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse". J. Biol. Chem. 275 (12): 8844–53. doi:10.1074/jbc.275.12.8844. PMID 10722730.
Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif". Biochem. J. 344 Pt 2 (Pt 2): 331–7. doi:10.1042/0264-6021:3440331. PMC 1220648. PMID 10567213.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165609 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025817 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10373642-5] McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol Med. 4 (1): 79–89. doi:10.3892/ijmm.4.1.79. PMID 10373642.

[entrez-6] 1 2 "Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5".

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References

Further reading