N-(Ethoxycarbonyl)phenethylamine

CAR-PEA
Clinical data
Other namesCAR-PEA; N-Ethoxycarbonyl-PEA
Drug classMonoamine releasing agent; Stimulant
ATC code
  • None
Identifiers
  • ethyl N-(2-phenylethyl)carbamate
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • CCOC(=O)NCCC1=CC=CC=C1
  • InChI=1S/C11H15NO2/c1-2-14-11(13)12-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3,(H,12,13)
  • Key:WXDDBYFBIIAYSM-UHFFFAOYSA-N

N-(Ethoxycarbonyl)phenethylamine (CAR-PEA) is a stimulant drug of the phenethylamine family related to phenethylamine (PEA).[1][2] It is the N-(ethoxycarbonyl) derivative of phenethylamine and hence is a carbamate derivative of this compound.[1][2] The drug is a prodrug of phenethylamine in rodents.[1][2] It has been shown to elevate brain levels of phenethylamine when given via intraperitoneal injection.[1][2] CAR-PEA was first described in the scientific literature by 1984.[1][2] Analogous carbamate prodrugs of amphetamine and tranylcypromine have also been described.[2]

See also

References

  1. 1 2 3 4 5 Coutts RT, Baker GB, Nazarali AJ, Rao TS, Micetich RG, Hall TW (1985). "Prodrugs of Trace Amines". Neuropsychopharmacology of the Trace Amines. Totowa, NJ: Humana Press. pp. 175–180. doi:10.1007/978-1-4612-5010-4_15. ISBN 978-1-4612-9397-2. Retrieved 30 May 2026.
  2. 1 2 3 4 5 6 Baker GB, Coutts RT, Nazarali AJ, Danielson TJ, Rubens M (1984). "Carbamate prodrugs of phenylethylamines: a neurochemical investigation". Proceedings of the Western Pharmacology Society. 27: 523–525. PMID 6494193.
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