Mika Kivimäki

Mika Juhani Kivimäki is a Finnish epidemiologist holding professorial positions at both University College London[1] and the University of Helsinki.[2]

Academic career

Kivimäki is the director of the Whitehall II Study, a long-term cohort study initiated in 1985 that investigates the social determinants of health among British civil servants.[3] He also leads several major international multicohort collaborations, including the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) consortium, which integrates data from 17 European cohort studies.[4]

Research contributions

Kivimäki’s research focuses on identifying modifiable risk factors for adult-onset chronic diseases.[5] He has authored over 1,400 peer-reviewed publications, significantly advancing understanding of midlife risk and protective factors in relation to conditions such as diabetes, cardiovascular disease, dementia, and multimorbidity.[6]

He is widely recognised for pioneering work in social epidemiology, particularly the associations between life stress, socioeconomic status, and chronic disease.[7][8][9][10][11] His research has also explored the role of prediabetes in the development of type 2 diabetes[12] and the impact of systemic inflammation and severe infections on depression, cognitive decline, and dementia.[13][14]

In recent years, Kivimäki has contributed to the field of biological ageing by linking obesity and social disadvantage to accelerated ageing.[15][16][17] By integrating longitudinal cohort data with proteomic biomarkers, his work has demonstrated the predictive value of organ-specific ageing signatures for future disease.[18]

Kivimäki serves as a scientific advisor to international health organisations, including the World Health Organization,[19] and contributes to global reports and commissions such as the Lancet Commissions.[20] His work has been cited in several clinical guidelines on disease prevention.[21][22][23][24]

Honours and recognition

Kivimäki is listed as a Highly Cited Researcher by Clarivate[25] and is ranked among the Best Medicine Scientists in the World by Research.com.[26] He is a Fellow of the Academy of Medical Sciences[27] and a member of the Academia Europaea.[28]

References

  1. ↑ https://www.ucl.ac.uk/epidemiology-health-care/people/professor-mika-kivimaki
  2. ↑ "Mika Kivimäki".
  3. ↑ "Whitehall II". UCL Faculty of Brain Sciences. University College London. Retrieved 25 July 2025.
  4. ↑ Kivimäki, Mika; Singh-Manoux, Archana; Virtanen, Marianna; Ferrie, Jane E.; Batty, G. David; Rugulies, Reiner (May 2015). "IPD-Work consortium: pre-defined meta-analyses of individual-participant data strengthen evidence base for a link between psychosocial factors and health". Scandinavian Journal of Work, Environment & Health. 41 (3): 312–321. doi:10.5271/sjweh.3485. PMID 25654401.
  5. ↑ "Professor Mika Kivimäki". University College London. Retrieved 25 July 2025.
  6. ↑ "ORCID". ORCID. Retrieved 25 July 2025.
  7. ↑ Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, Bjorner JB, Borritz M, Burr H, Casini A, Clays E, De Bacquer D, Dragano N, Ferrie JE, Geuskens GA, Goldberg M, Hamer M, Hooftman WE, Houtman IL, Joensuu M, Jokela M, Kittel F, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Kumari M, Madsen IE, Marmot MG, Nielsen ML, Nordin M, Oksanen T, Pentti J, Rugulies R, Salo P, Siegrist J, Singh-Manoux A, Suominen SB, Väänorell T; IPD-Work Consortium (October 2012). "Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data". The Lancet. 380 (9852): 1491–1497. doi:10.1016/S0140-6736(12)60994-5. PMC 3486012. PMID 22981903.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ↑ Stringhini, Silvia; Carmeli, Cristian; Jokela, Markus; Avendaño, Mauricio; McCrory, Cathal; d'Errico, Angelo; Barros, Henrique; Costa, Giuseppe; Chadeau-Hyam, Marc; Delpierre, Céline; Fraga, Sílvia; Goldberg, Marcel; Hajdu, Tibor; Kauhanen, Jussi; Layte, Richard; Leineweber, Constanze; Magnusson Hanson, Linda L; Muennig, Peter; Ortega, Francisco B; Pikhart, Hynek; Rugulies, Reiner; Steptoe, Andrew; Shipley, Martin J; Vollenweider, Peter; Zins, Marie; Kawachi, Ichiro; Mackenbach, Johan P; Vineis, Paolo; Kivimäki, Mika (25 March 2017). "Socioeconomic status and the 25×25 risk factors as determinants of premature mortality: a multicohort study of 1.7 million men and women" (PDF). The Lancet. 389 (10075): 1229–1237. doi:10.1016/S0140-6736(16)32380-7. PMC 5368415. PMID 28159391. Retrieved 25 July 2025.
  9. ↑ Kivimäki, M; Steptoe, A (April 2018). "Effects of stress on the development and progression of cardiovascular disease". Nature Reviews Cardiology. 15 (4): 215–229. doi:10.1038/nrcardio.2017.189. PMID 29213140. Retrieved 21 July 2025.
  10. ↑ Kivimäki, M; Batty, GD; Pentti, J; Shipley, MJ; Sipilä, PN; Nyberg, ST; Suominen, SB; Oksanen, T; Stenholm, S; Virtanen, M; Marmot, MG; Singh-Manoux, A; Brunner, EJ; Lindbohm, JV; Ferrie, JE; Vahtera, J (March 2020). "Association of socioeconomic status with the development of mental and physical health conditions in adulthood: a multi-cohort study". Lancet Public Health. 5 (3): e140–e149. doi:10.1016/S2468-2667(20)30011-7 (inactive 26 July 2025). Retrieved 21 July 2025.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
  11. ↑ Kivimäki, M; Bartolomucci, A; Kawachi, I (January 2023). "The multiple roles of life stress in metabolic disorders". Nature Reviews Endocrinology. 19 (1): 10–27. doi:10.1038/s41574-022-00746-8. PMC 10817208. PMID 36520794.
  12. ↑ Tabák, AG; Herder, C; Rathmann, W; Brunner, EJ; Kivimäki, M (June 2012). "Prediabetes: a high-risk state for diabetes development". The Lancet. 379 (9833): 2279–2290. doi:10.1016/S0140-6736(12)60283-9. PMC 3891203. PMID 22683128.
  13. ↑ Sipilä, PN; Heikkilä, N; Lindbohm, JV; Hakulinen, C; Vahtera, J; Elovainio, M; Suominen, S; Väänänen, A; Koskinen, A; Nyberg, ST; Pentti, J; Strandberg, TE; Kivimäki, M (November 2021). "Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort". The Lancet Infectious Diseases. 21 (11): 1557–1567. doi:10.1016/S1473-3099(21)00144-4. PMC 8592915. PMID 34166620.
  14. ↑ Haapakoski, R; Mathieu, J; Ebmeier, KP; Alenius, H; Kivimäki, M (October 2015). "Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder". Brain, Behavior, and Immunity. 49: 206–215. doi:10.1016/j.bbi.2015.06.001. PMID 26093231. Retrieved 21 July 2025.
  15. ↑ Kivimäki, M; Strandberg, T; Pentti, J; Nyberg, ST; Frank, P; Jokela, M; Ervasti, J; Suominen, SB; Vahtera, J; Sipilä, PN; Lindbohm, JV; Ferrie, JE (April 2022). "Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study". The Lancet Diabetes & Endocrinology. 10 (4): 253–263. doi:10.1016/S2213-8587(22)00033-X. PMC 8938400. PMID 35248171.
  16. ↑ Kivimäki, M; Frank, P; Pentti, J; Xu, X; Vahtera, J; Ervasti, J; Nyberg, ST; Lindbohm, JV; Jokela, M; Partridge, L (July 2024). "Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study". The Lancet Healthy Longevity. 5 (7): e454–e463. doi:10.1016/S2666-7568(24)00087-4. PMID 38945128. Retrieved 21 July 2025.
  17. ↑ Kivimäki, Mika; Pentti, Jaana; Frank, Philipp; Liu, Fangyu; Blake, Acer; Nyberg, Solja T.; Vahtera, Jussi; Singh-Manoux, Archana; Wyss-Coray, Tony; Walker, Keenan A.; Partridge, Linda; Lindbohm, Joni V. (2025). "Social disadvantage accelerates aging". Nature Medicine. 31 (5): 1635–1643. doi:10.1038/s41591-025-03563-4. PMC 12092251. PMID 40087516.
  18. ↑ Kivimäki, M; Frank, P; Pentti, J; Jokela, M; Nyberg, ST; Blake, A; Lindbohm, JV; Oh, HSH; Singh-Manoux, A; Wyss-Coray, T; Partridge, L (March 2025). "Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study". The Lancet Digital Health. 7 (3): e195–e204. doi:10.1016/j.landig.2025.01.006. PMID 40015764. Retrieved 21 July 2025.
  19. ↑ Optimizing brain health across the life course: WHO position paper. Geneva: World Health Organization. 2022. ISBN 9789240054561. Retrieved 21 July 2025.
  20. ↑ Livingston, G; Huntley, J; Liu, KY; Costafreda, SG; Selbæk, G; Alladi, S; Ames, D; Banerjee, S; Burns, A; Brayne, C; Fox, NC; Ferri, CP; Gitlin, LN; Howard, R; Kales, HC; Kivimäki, M; Larson, EB; Nakasujja, N; Rockwood, K; Samus, Q; Shirai, K; Singh-Manoux, A; Schneider, LS; Walsh, S; Yao, Y; Sommerlad, A; Mukadam, N (August 2024). "Dementia prevention, intervention, and care: 2024 report of the Lancet Standing Commission". The Lancet. 404 (10452): 572–628. doi:10.1016/S0140-6736(24)01296-0. PMID 39096926. Retrieved 21 July 2025.
  21. ↑ Visseren, FLJ; Mach, F; Smulders, YM; Carballo, D; Koskinas, KC (2021). "2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies with the special contribution of the European Association of Preventive Cardiology (EAPC)". European Heart Journal. 42 (34): 3227–3337. doi:10.1093/eurheartj/ehab484. PMID 34458905.
  22. ↑ Marx, N; Federici, M; Schütt, K; Müller-Wieland, D; Ajjan, RA (2023). "2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes: Developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC)". European Heart Journal. 44 (39): 4043–4140. doi:10.1093/eurheartj/ehad192. PMID 37622663.
  23. ↑ "Cardiovascular disease: risk assessment and reduction, including lipid modification: Evidence review for CVD risk assessment tools – primary prevention". NICE Guideline NG238. National Institute for Health and Care Excellence (NICE). 14 December 2023. Retrieved 22 July 2025.
  24. ↑ Hampl, SE; Hassink, SG; Skinner, AC (2023). "Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity". Pediatrics. 151 (2): e2022060640. doi:10.1542/peds.2022-060640. PMID 36622115.
  25. ↑ "Highly Cited Researchers | Clarivate". 13 November 2024.
  26. ↑ "Mika Kivimäki: Medicine H-index & Awards - Academic Profile".
  27. ↑ "Professor Mika Kivimaki".
  28. ↑ "Academy of Europe: Kivim%C3%A4ki Mika".
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