Maura L. Gillison

Maura L. Gillison
Born(1965-01-04)January 4, 1965
DiedJune 21, 2026(2026-06-21) (aged 61)
Spouse
David E. Symer
​
(m. 1992)​
Children2
Academic background
EducationBSc, Zoology, 1987, Duke University
MD, 1991, Johns Hopkins University School of Medicine
PhD, 2001, Johns Hopkins Bloomberg School of Public Health
ThesisEvidence for a causal association between human papillomavirus and a subset of head and neck cancers (2001)
Academic work
InstitutionsMD Anderson Cancer Center
Ohio State University Comprehensive Cancer Center
Johns Hopkins University

Maura Lianne Gillison (January 4, 1965 – June 21, 2026) was an American medical oncologist and molecular epidemiologist. She is credited as the first investigator to establish a definitive connection between HPV and oral cancer.

Early life and education

Gillison was born in London, Ontario, on January 4, 1965, and moved frequently with her family in the United States and Mexico.[1][2][3] She graduated from Hathaway Brown School in Shaker Heights, Ohio, in 1983. She completed her Bachelor of Science degree in zoology from Duke University before moving to Maryland to attend the Johns Hopkins University School of Medicine (JHUSOM), from which she received her medical degree in 1991.[4]

Gillison completed her internship in internal medicine at Johns Hopkins Hospital in 1993 and medical residency training at Massachusetts General Hospital in Boston, Massachusetts, in 1995. She returned to Baltimore in 1996 for clinical fellowship training in medical oncology at the Johns Hopkins Oncology Center. She attended the Graduate Training Program in Clinical Investigation at the Johns Hopkins Bloomberg School of Public Health, from which she received the PhD degree in 2001.

As a graduate student in Professor Keerti Shah's laboratory, Gillison wrote a landmark paper published in 2000 in the Journal of the National Cancer Institute which demonstrated a link between human papillomavirus virus (HPV)-16 and oropharyngeal cancers.[5] She is credited as the first investigator to establish a connection between HPV and oral cancer.[6] She later stated that although the paper impacted her entire career, she was "having so much fun that I didn’t realize its implications".[2] Following her time at JHU, Gillison was inducted as a member of Delta Omega, an honorary society for studies in public health.[7]

Career

Following publication of her landmark 2000 study, Gillison was the senior author of the groundbreaking 2007 New England Journal of Medicine study "Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer" showing that HPV 16 infection results in head and neck squamous cell carcinoma (HNSCCs) in both men and women, and that having multiple oral sex partners increases the risk for developing these cancers.[8] The following year, Gillison and her research team described distinct risk factor profiles for HPV16–positive and HPV16–negative HNSCCs.[6]

Gillison was recruited from Johns Hopkins in 2009 to join the Ohio State University Comprehensive Cancer Center with research grants from the National Cancer Institute (NCI). In the same year, she presented data at the American Society of Clinical Oncology (ASCO) conference showing that HPV is the most important predictor of clinical response to tumor therapy and prognosis for patients with these cancers. As a result of her work, the NCI recommended that clinical trials in HNSCC stratify tumors by HPV status.[9]

Gillison advocated for inclusion of boys and men in anti-HPV vaccination efforts. She stated: "The time has come to have a more thorough discussion about the potential benefits of HPV vaccines in boys … When my patients ask whether they should vaccinate their sons [with the HPV vaccine], I say ‘certainly’. The vaccine will protect them against genital warts and anal cancer and—as a potential by-product of that—it may protect them against oral cancer caused by HPV … The time has come to consider offering the HPV vaccine to boys."[10][11] She and her colleagues subsequently showed that the HPV vaccine dramatically reduced the prevalence of oral HPV infections in vaccinated vs unvaccinated men.[12]

She was inducted into the American Society for Clinical Investigation.[13] She was also honored by the American Association for Cancer Research with the 2012 Richard and Hinda Rosenthal Memorial Award.[14]

As the Jeg Coughlin Chair in Cancer Research, professor in the division of medical oncology, and member of the cancer control program at the Ohio State University Comprehensive Cancer Center, Gillison was elected a member of the National Academy of Medicine.[15] She was also inducted into JHU's Society of Scholars in 2016.[16]

In 2017, Gillison joined the MD Anderson Cancer Center to continue her research into HPV-caused cancers. She continued to investigate the genetic and genomic changes induced by HPV that transform human cells, [2] and studied immunological responses to HPV-associated cancers, to improve anti-cancer therapies.[17]

Gillison was inducted into the 2020 class of Giants of Cancer Care, awarded for Translational Science.[18]

She was the recipient of the 2021 David A. Karnofsky Memorial Award and Lecture from American Society of Clinical Oncology.[19]

In 2024, Gillison was awarded the Potu N. Rao Award for Excellence in Basic Science at University of Texas MD Anderson Cancer Center in Houston, Texas. [20]

In December 2025, Gillison was awarded the VinFuture Grand Prize together with laureates Drs. Douglas R. Lowy, John T. Schiller and Aimée R. Kreimer of the U.S. National Cancer Institute, in Hanoi, Vietnam. [21]

Personal life and death

Gillison married David E. Symer in 1992; he is an oncologist and physician-scientist.[1] They had two daughters.[1] She died in Willoughby, Ohio, on June 21, 2026, from cancer of the small intestine.[1][22][23]

References

  1. 1 2 3 4 Longman, Jeré (August 9, 2026). "Dr. Maura L. Gillison, Who Linked Throat Cancers to HPV, Dies at 61". The New York Times. Retrieved August 9, 2026.
  2. 1 2 3 Piana, Ronald (September 10, 2019). "Maura L. Gillison, MD, PhD, Pioneer in HPV-Related Head and Neck Cancer, Has Often Changed Lanes in Her Career". ascopost.com. Retrieved May 28, 2021.
  3. ↑ Hagerty, James R. (2026-07-10). "Maura Gillison, Who Transformed the Treatment of Mouth and Throat Cancers, Dies at 61". Wall Street Journal. ISSN 0099-9660. Retrieved 2026-07-11.
  4. ↑ "Maura L. Gillison, MD, PhD". mdanderson.org. Retrieved May 28, 2021.
  5. ↑ https://academic.oup.com/jnci/article-abstract/92/9/709/2906131?redirectedFrom=PDF
  6. 1 2 Harris, Jason (2020). "OncLive Honors 15 Cancer Care Pioneers". onclive.com. Vol. 21/No. 19. 21. OncLive. Retrieved May 28, 2021.
  7. ↑ "Delta Omega 2001 Inductees". jhsph.edu. Retrieved May 28, 2021.
  8. ↑ D'Souza, Gypsyamber; Kreimer, Aimee R.; Viscidi, Raphael; Pawlita, Michael; Fakhry, Carole; Koch, Wayne M.; Westra, William H.; Gillison, Maura L. (May 10, 2007). "Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer". New England Journal of Medicine. 356 (19): 1944–1956. doi:10.1056/NEJMoa065497. PMID 17494927.
  9. ↑ "Maura Gillison". oralcancerfoundation.org. 20 September 2016. Retrieved May 28, 2021.
  10. ↑ Jha, Alok (2011-02-20). "Scientist urges human papilloma virus jabs for boys to stem oral cancer rise". The Guardian. ISSN 0261-3077. Retrieved 2026-07-11.
  11. ↑ Gillison, Maura L.; Chaturvedi, Anil K.; Lowy, Douglas R. (2008-11-15). "HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women". Cancer. 113 (S10): 3036–3046. doi:10.1002/cncr.23764. ISSN 1097-0142. PMC 6264789. PMID 18980286.
  12. ↑ Chaturvedi, Anil K.; Graubard, Barry I.; Broutian, Tatevik; Pickard, Robert K.L.; Tong, Zhen-Yue; Xiao, Weihong; Kahle, Lisa; Gillison, Maura L. (2018-01-20). "Effect of Prophylactic Human Papillomavirus (HPV) Vaccination on Oral HPV Infections Among Young Adults in the United States". Journal of Clinical Oncology. 36 (3): 262–267. doi:10.1200/JCO.2017.75.0141. ISSN 0732-183X. PMC 5773841. PMID 29182497.
  13. ↑ "Maura L. Gillison, MD, PhD". the-asci.org. American Society for Clinical Investigation. Retrieved May 28, 2021.
  14. ↑ "Gillison Lands Rosenthal Memorial Award for HPV Work in Cancer". cancer.osu.edu. 2012. Retrieved May 28, 2021.
  15. ↑ "Prominent National Organization Honors Prolific Ohio State Scientist Physician". cancer.osu.edu. November 8, 2016. Retrieved May 28, 2021.
  16. ↑ "Johns Hopkins inducts 16 new members into Society of Scholars". hub.jhu.edu. April 12, 2016. Retrieved May 28, 2021.
  17. ↑ Jiang, Xianli; Rudqvist, Nils-Petter; Jiang, Bo; Ye, Shengbin; He, Shan; Liang, Qingnan; Dou, Jinzhuang; Williams, Michelle D.; Dunn, Joe Dan; Johnson, Jason M.; Akagi, Keiko; Xiao, Weihong; Liang, Xiaoheng; Elayavalli, Satvik; Sun, Baohua; Parra, Edwin R.; Ferrarotto, Renata; Garden, Adam S.; Fuller, Clifton David; Reddy, Jay; Gross, Neil D.; Lango, Miriam N.; Leung, Cheuk Hong; Liu, Suyu; Liu, Diane D.; Li, Meng; Lee, J. Jack; Curran, Michael A.; Phan, Jack; Chen, Ken; Gillison, Maura L. "Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade". Cancer Discovery. 15 (8): 1569–1592. doi:10.1158/2159-8290.CD-24-1390. ISSN 2159-8290. PMC 12319410. PMID 40249124.
  18. ↑ Staff, The ASCO Post. "2020 Class of Giants of Cancer Care Announced". ascopost.com. Retrieved 2026-07-11.
  19. ↑ "ASCO recognizes three MD Anderson faculty with highest honors". mdanderson.org. April 22, 2021. Retrieved May 28, 2021.
  20. ↑ "Maura L. Gillison". UT MD Anderson. Retrieved 2026-07-11.
  21. ↑ "Professor Maura L. Gillison". VinFuture Prize. Retrieved 2026-07-11.
  22. ↑ "Maura Gillison, who identified the role of HPV in head and neck cancer, changing the standard of care, dies at 61". TheCancerLetter.
  23. ↑ "Maura Gillison, Who Transformed the Treatment of Mouth and Throat Cancers, Dies at 61". Wall Street Journal.