Markku Laakso

Markku Laakso (born 1949 in Vampula) is a Finnish professor of medicine and a type 2 diabetes researcher. He was awarded the Matti Äyräpää Prize in 2007, the Kelly West Award in 2008, and the Finnish Science Award in 2015.[1]

Laakso’s research focuses on the molecular genetics of type 2 diabetes and its cardiovascular complications. He has participated in numerous international clinical trials and genetic studies, including FUSION (Finland–United States Investigation of Type 2 Diabetes Genetics), a large-scale collaboration aimed at identifying susceptibility genes, and METSIM (Metabolic Syndrome in Men), a longitudinal cohort of over 10,000 men used to identify genetic variants and biomarkers associated with insulin resistance.[2]

Research he co-authored has examined the Pro12Ala polymorphism of the PPARG in relation to insulin sensitivity and diabetes risk.[3] Further collaborative studies have reported that the Ala12Ala genotype is associated with lower carotid intima-media thickness, a marker of subclinical atherosclerosis, suggesting a potential protective effect.[4]

References

  1. ↑ "Academy Professor Markku Laakso wins Finnish Science Award - News". www.uef.fi. University of Eastern Finland. 2015-05-20. Archived from the original on 2019-07-01. Retrieved 2019-07-01.
  2. ↑ Laakso, Markku; Kuusisto, Johanna; Stančáková, Alena; Kuulasmaa, Teemu; Pajukanta, Päivi; Lusis, Aldons J.; Collins, Francis S.; Mohlke, Karen L.; Boehnke, Michael (March 2017). "The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases". Journal of Lipid Research. 58 (3): 481–493. doi:10.1194/jlr.O072629. ISSN 1539-7262. PMC 5335588. PMID 28119442.
  3. ↑ Deeb, S. S.; Fajas, L.; Nemoto, M.; Pihlajamäki, J.; Mykkänen, L.; Kuusisto, J.; Laakso, M.; Fujimoto, W.; Auwerx, J. (November 1998). "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity". Nature Genetics. 20 (3): 284–287. doi:10.1038/3099. ISSN 1061-4036. PMID 9806549.
  4. ↑ Temelkova-Kurktschiev, Theodora; Hanefeld, Markolf; Chinetti, Giulia; Zawadzki, Christophe; Haulon, Stephan; Kubaszek, Agata; Koehler, Carsta; Leonhardt, Wolfgang; Staels, Bart; Laakso, Markku (September 2004). "Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis". The Journal of Clinical Endocrinology and Metabolism. 89 (9): 4238–4242. doi:10.1210/jc.2003-032120. ISSN 0021-972X. PMID 15356014.


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