Mark T. Gladwin

Mark T. Gladwin
Alma materUniversity of Miami
Scientific career
FieldsHeart and vascular medicine
WorkplacesNational Institutes of Health
University of Pittsburgh
University of Maryland School of Medicine
WebsiteUniversity of Maryland School of Medicine Office of the Dean

Mark T. Gladwin is an American physician-scientist and academic administrator serving as the dean of the University of Maryland School of Medicine since 2022.[1][2] He is also the John Z. and Akiko K. Bowers Distinguished Professor and vice president for medical affairs of the University of Maryland, Baltimore.[3][4]

Education and career

Gladwin earned a B.S. and M.D. (1991) through the 6-year B.S.-M.D. honors program in medical education at University of Miami .[5] He completed an internal medicine internship and residency in 1994 and served as chief resident in 1995 at the Oregon Health & Science University.[5] He was a critical care fellow at the National Institutes of Health Clinical Center in 1996.[5] In 1998, he completed a fellowship in pulmonary critical care at the University of Washington.[5] He returned to the NIH Clinical Center as a senior research fellow in critical care medicine until 2000, also serving as the Chief of the Pulmonary and Vascular Medicine Branch of the National Heart, Lung, and Blood Institute.[6][5]

Gladwin joined the University of Pittsburgh School of Medicine in 2008 as a professor and Division Chief of Pulmonary, Allergy and Critical Care Medicine, and also served as the inaugural director of the university's Vascular Medicine Institute.[7][8] In 2015, he was appointed chair of the department of medicine.[9] By the time Gladwin left the university in 2022, the department employed more than 1,000 faculty and had combined clinical and research revenues of almost $600 million.[9][10]

University of Maryland

On August 1, 2022, Gladwin was appointed dean of the University of Maryland School of Medicine,[5][1] succeeding longtime dean E. Albert Reece.[8] He oversees 46 academic departments with a total annual operating budget of $1.3 billion and more than 7,000 faculty, trainees, students and staff.[11]

Since becoming dean, Gladwin has helped launched new institutes and initiatives focusing on addiction medicine, health computing/ AI, neuroscience, bioengineering, new venture formation, and community health.[12]

The Kahlert Institute for Addiction Medicine, within the school of medicine, focuses on understanding the underpinnings of addiction, uncovering new approaches to the treatment of opioid use disorder, bringing together neuroscientists studying the brain mechanisms underlying addictions and physician educators working to train a new generation of medical students and residents.[13][14] The medical school's Medicine Institute for Neuroscience Discovery (UM-MIND) focuses on  neurodevelopment and neuropsychiatric disorders, neurotrauma and brain injury, as well as aging and neurodegeneration.[15][16]

To consolidate and amplify the school of medicine's global footprint in clinical care, research and education, Gladwin formed the Global Health Alliance focusing on improving health outcomes in developing countries through research collaborations and capacity building.[17]

Gladwin was also involved in establishing the University of Maryland Institute for Health Computing (UM-IHC), located in North Bethesda, Maryland, which applies artificial intelligence and bioinformatics techniques to health data to support drug discovery, population health, and other computationally intensive research areas. He noted that he sees this part of Maryland “becoming the East Coast Silicon Valley of health computing.[18][19]

Gladwin's other major initiatives for the school of medicine include addressing the doctor shortage in Maryland.[20] He established the Rural-MD Scholars Program, which trains medical students in caring for patients in Maryland's Eastern Shore region and aims to reduce the shortage of clinicians in rural practice. He also helped establish the Edward & Jennifer St. John Center for Translational Engineering and Medicine, which brings together engineering and clinical faculty to research bioengineering solutions to medical challenges.[21]

In 2025, Gladwin, along with other leaders from the University of Maryland, Baltimore, and the University of Maryland Medical System, announced the receipt of a $50 million donation from billionaire philanthropist Tom Golisano. The donation, the largest in the institution's history, will fund renovations to what is now known as the University of Maryland Golisano Children's Hospital, within the University of Maryland Medical Center.[22][23]

Gladwin has also recruited new leadership in multiple academic departments, including internationally recognized inflammatory skin disorder expert Shawn Kwatra to chair the department of dermatology and leading pulmonologist Roberto Machado to chair the school's department of medicine[24][25][26] Gladwin also recruited leading neuroanesthesiology expert David Mintz to chair the department of anesthesiology, maternal health researcher Andreea Creanga to chair the department of epidemiology and public health, Tarek Hanna, an expert in emergency and trauma radiology, as chair of the department of diagnostic radiology and nuclear medicine,[27][28][29] and Irina Burd, the Sylvan Frieman, MD Endowed Professor, as Chair of the Department of Obstetrics, Gynecology & Reproductive Science.[30] He hired new leaders for the school's research institutes, such as Elana Fertig to take the helm of the Institute for Genome Sciences, malaria vaccine researcher Stefan Kappe to direct the school's Center for Vaccine Development and Global Health, and Bradley A. Maron to co-direct the Institute for Health Computing.[31][32][33][34][35]

Authorship

Gladwin is co-author of two medical textbooks in the "Made Ridiculously Simple" series from publisher Medmaster Inc. He wrote Clinical Microbiology Made Ridiculously Simple with physicians William Trattler and C. Scott Mahan, and Critical Care and Hospitalist Medicine Made Ridiculously Simple with physician Michael Donahoe.[36][37]

Research

Gladwin is a vascular, heart, and lung physician-scientist who has specialized in the study of reactive nitrogen molecules, like nitric oxide and nitrite, and how they regulate blood flow via reactions with hemoglobin. Researchers in the late 1970s[38] discovered that nitric oxide (NO) regulated blood flow by triggering vasodilation, the widening of blood vessels. However, scientists considered metabolites of NO, such as nitrite (NO2−), to be inert.[39] But in 2003, Gladwin and a team of researchers published a paper in Nature Medicine demonstrating that nitrite could also trigger vasodilation, through conversion to NO, under low oxygen conditions in the body such as during a heart attack or stroke.[40] Subsequent studies by other researchers suggest nitrite administered before or immediately following a heart attack could help preserve heart tissue.[41]

Gladwin has also conducted research on hemoglobin-related proteins, such as neuroglobin, and their possible application as antidotes to carbon monoxide poisoning.[42][43][44] He currently serves as chair of the Board of Directors of Globin Solutions, Inc., a pre-clinical stage biopharmaceutical company researching rapidly acting antidotes for carbon monoxide poisoning, including a modified form of neuroglobin.[45][46] In December 2023, Gladwin and his team of researchers published a study in Nature Communications on the discovery of the first-ever link between hemoglobin-like protein and normal cardiac development.[47]

Gladwin's work on blood flow and hemoglobin also led to discoveries related to sickle cell disease.[48] In 2004, Gladwin and his colleagues found that 10% of sickle cell patients also exhibited pulmonary hypertension, high blood pressure in the blood vessels that supply the lung, and determined that hypertension was a major cause of death among sickle cell patients. They described this new human disease syndrome, called hemolysis-associated pulmonary hypertension, in the New England Journal of Medicine.[49]

In June 2020, Gladwin initiated a 22-site Phase II clinical trial in France, Brazil, and the U.S. that is exploring whether blood transfusions that use the patient's own blood can improve outcomes and extend survival in patients with sickle cell disease.[50][51]

In 2025, Gladwin was named that year's recipient of the Assembly on Pulmonary Circulation Leadership Award from the American Thoracic Society.[52]

In April 2026, University of Miami Miller School of Medicine honored Gladwin with the school's Medical Alumni Hall of Fame Award in recognition of his discoveries around nitrite signaling and pulmonary hypertension in sickle cell disease, as well as his overall career achievements to date.[53]

Personal life

Dr. Gladwin was born in Palo Alto, California, and was raised in various locations in the United States as well as in remote locations in Ghana, Guatemala, and Mexico. His parents, Hugh Gladwin, Ph.D., a professor of anthropology at Florida International University, and Christina Gladwin, Ph.D., a professor of food and resource economics at the University of Florida, studied in these locations.

He is married to Dr. Tammy Shields, an epidemiologist and scientific investigator who has published research on cancer epidemiology and prevention. They have three children.

References

  1. 1 2 Staff, Daily Record (2024-04-30). "Mark T. Gladwin". Maryland Daily Record. Retrieved 2025-12-04.
  2. ↑ Parker, Kevin (2025-12-17). "David Mintz, MD, PhD, Named Chair of the Department of Anesthesiology at the UM School of Medicine". citybiz. Retrieved 2026-01-02.
  3. ↑ Baltimore, University of Maryland. "Mark T. Gladwin, MD". University of Maryland, Baltimore. Retrieved 2024-01-12.
  4. ↑ Daily Record Staff (2022-04-20). "Next dean, VP of medical affairs for UM School of Medicine selected". Maryland Daily Record. Retrieved 2024-01-12.
  5. 1 2 3 4 5 6 "Gladwin, Mark | University of Maryland School of Medicine". www.medschool.umaryland.edu. Retrieved 2023-12-26.
  6. ↑ "Vascular Medicine Branch, Division of Intramural Research, NHLBI, NIH". dir.nhlbi.nih.gov. Archived from the original on September 29, 2006. Retrieved 2024-01-12.
  7. ↑ "Mark T. Gladwin, MD". vmi.pitt.edu. Retrieved 2026-04-20.
  8. 1 2 Cohn, Meredith (2022-04-20). "University of Maryland School of Medicine names Pittsburgh medical professor as new dean". Baltimore Sun. Retrieved 2023-12-26.
  9. 1 2 "Gladwin Named Department of Medicine Chair at Pitt School of Medicine". UPMC | Life Changing Medicine. Retrieved 2024-02-15.
  10. ↑ "Noted physician-scientist, Anne Marie Lennon, MBBCh, PhD, named Chair of Medicine". Department of Medicine. 2023-11-20. Retrieved 2024-08-14.
  11. ↑ Daily Record Staff (2022-10-18). "FEATURED MOVER | Dr. Mark Gladwin, UMD School of Medicine". Maryland Daily Record. Retrieved 2024-02-15.
  12. ↑ UMMCVideos (2024-03-14). Chat with the Chair Podcast Series: Special Dean Episode. Retrieved 2026-04-15 – via YouTube.
  13. ↑ True, Sarah (2023-05-31). "U. of Maryland medical school opens addiction research institute". The Banner. Retrieved 2026-04-15.
  14. ↑ "University of Maryland medical school launches $30M addiction research center". Baltimore Business Journal. 2023-05-31. Retrieved 2026-04-15.
  15. ↑ Daily Record Staff, Daily Record Staff (December 16, 2022). "University Of Md. School of Medicine launches Md. Institute for Neuroscience Discovery". The Daily Record. Retrieved April 15, 2026.
  16. ↑ "Five Questions with Margaret McCarthy, Membership Engagement Chair for Section V (Neuroscience) | American Association for the Advancement of Science (AAAS)". American Association for the Advancement of Science (AAAS). Archived from the original on 2025-06-24. Retrieved 2026-04-15.
  17. ↑ "UMSOM Creates Global Health Alliance - Alumni and Donors". www.umaryland.edu. Retrieved 2026-04-15.
  18. ↑ "Baltimore researchers say AI could help reduce disparities, improve access in health care". Baltimore Sun. 2023-01-29. Retrieved 2026-04-15.
  19. ↑ Althouse, Michaela (2022-11-10). "UMD schools and Montgomery County are teaming up to launch an institute for health computing". Technical.ly. Retrieved 2026-04-15.
  20. ↑ Engel, Amanda (2025-12-09). "University of Maryland School of Medicine expands class size to address doctor shortage". WMAR 2 News Baltimore. Retrieved 2026-04-15.
  21. ↑ "New $2.4 Million Investment in Medical Program to Put More Doctors on the Shore - Talbot Spy". talbotspy.org. Retrieved 2026-04-15.
  22. ↑ Oklobzija, Kevin (October 28, 2025). "University of Maryland Children's Hospital receives $50M from NY philanthropist". The Daily Record. p. 1. Retrieved April 15, 2026.
  23. ↑ Hoffman, Hannah (2025-10-28). "UM Children's Hospital receives record $50M gift from philanthropist". WBAL. Retrieved 2026-04-15.
  24. ↑ Bader, Kaitlyn (2026-04-15). "Shawn Kwatra, MD, Endowed as Dr. Joseph Warren Burnett Professor of Dermatology at the University of Maryland School of Medicine | Dermatology Times". www.dermatologytimes.com. Retrieved 2026-04-15.
  25. ↑ Contreras, Briana (2026-04-15). "Insights Into Chronic Itch From Shawn Kwatra, M.D. | Managed Healthcare Executive". www.managedhealthcareexecutive.com. Retrieved 2026-04-15.
  26. ↑ "DISTINGUISHED PHYSICIAN-SCIENTIST AND NATIONALLY RECOGNIZED PULMONOLOGIST ROBERTO MACHADO, MD, NAMED CHAIR OF THE DEPARTMENT OF MEDICINE AT THE UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE". AP News. 2025-07-23. Retrieved 2026-04-15.
  27. ↑ "Nationally Renowned Anesthesiology Physician-Scientist and Clinical Operations Leader David Mintz, MD, PhD, Named Chair of the Department of Anesthesiology at the UM School of Medicine". AP News. 2025-12-17. Retrieved 2026-04-15.
  28. ↑ Daily Record Staff, Daily Record Staff (October 7, 2025). "Andreea Creanga | University of Maryland School of Medicine". The Daily Record. Retrieved April 15, 2026.
  29. ↑ "University of Maryland names new radiology chair". radiologybusiness.com. 2025-05-19. Retrieved 2026-04-15.
  30. ↑ "2022 Archive". www.medschool.umaryland.edu. Retrieved 2026-04-27.
  31. ↑ Parker, Kevin (2024-09-02). "UMSOM Appoints Elana Fertig as Director of the School's Institute for Genome Sciences". citybiz. Retrieved 2026-04-15.
  32. ↑ Bioengineer (2025-09-08). "Stefan Kappe, Ph.D., Renowned Malaria Researcher, Named Director of UM". BIOENGINEER.ORG. Retrieved 2026-04-15.
  33. ↑ Daily Record Staff, Daily Record Staff (September 12, 2025). "Stefan Kappe | Center for Vaccine Development and Global Health". The Daily Record. Retrieved April 15, 2026.
  34. ↑ "Maron Will Co-Direct Institute for Health Computing - News". www.umaryland.edu. Retrieved 2026-04-27.
  35. ↑ "Bradley Maron MD'03 set to become new editor-in-chief of Circulation". The Brown Daily Herald. Retrieved 2026-04-27.
  36. ↑ "Clinical Microbiology Made Ridiculously Simple". MedMaster. Retrieved 2024-03-15.
  37. ↑ "Critical Care and Hospitalist Medicine Made Ridiculously Simple". MedMaster. Retrieved 2024-03-15.
  38. ↑ Ignarro, Louis J. (2000), "Nitric Oxide in the Regulation of Blood Flow: A Historical Overview", in Kadowitz, Philip J.; McNamara, Dennis B. (eds.), Nitric Oxide and the Regulation of the Peripheral Circulation, Nitric Oxide in Biology and Medicine, Boston, MA: Birkhäuser, pp. 1–12, doi:10.1007/978-1-4612-1326-0_1, ISBN 978-1-4612-1326-0, retrieved 2024-01-12
  39. ↑ Wink, David A. (December 2003). "Ion implicated in blood pact". Nature Medicine. 9 (12): 1460–1461. doi:10.1038/nm1203-1460. ISSN 1546-170X. PMID 14647519. S2CID 29815156.
  40. ↑ Cosby, Kenyatta; Partovi, Kristine S.; Crawford, Jack H.; Patel, Rakesh P.; Reiter, Christopher D.; Martyr, Sabrina; Yang, Benjamin K.; Waclawiw, Myron A.; Zalos, Gloria; Xu, Xiuli; Huang, Kris T.; Shields, Howard; Kim-Shapiro, Daniel B.; Schechter, Alan N.; Cannon, Richard O. (December 2003). "Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation". Nature Medicine. 9 (12): 1498–1505. Bibcode:2003NatMe...9.1498C. doi:10.1038/nm954. ISSN 1546-170X. PMID 14595407. S2CID 6370323.
  41. ↑ Griffiths, Kayleigh; Lee, Jordan J.; Frenneaux, Michael P.; Feelisch, Martin; Madhani, Melanie (2021-07-01). "Nitrite and myocardial ischaemia reperfusion injury. Where are we now?". Pharmacology & Therapeutics. 223 107819. doi:10.1016/j.pharmthera.2021.107819. ISSN 0163-7258. PMID 33600852. S2CID 231963701.
  42. ↑ Azarov, Ivan; Wang, Ling; Rose, Jason J.; Xu, Qinzi; Huang, Xueyin N.; Belanger, Andrea; Wang, Ying; Guo, Lanping; Liu, Chen; Ucer, Kamil B.; McTiernan, Charles F.; O’Donnell, Christopher P.; Shiva, Sruti; Tejero, Jesús; Kim-Shapiro, Daniel B. (2016-12-07). "Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning". Science Translational Medicine. 8 (368): 368ra173. doi:10.1126/scitranslmed.aah6571. ISSN 1946-6234. PMC 5206801. PMID 27928027.
  43. ↑ Rose, Jason J.; Bocian, Kaitlin A.; Xu, Qinzi; Wang, Ling; DeMartino, Anthony W.; Chen, Xiukai; Corey, Catherine G.; Guimarães, Danielle A.; Azarov, Ivan; Huang, Xueyin N.; Tong, Qin; Guo, Lanping; Nouraie, Mehdi; McTiernan, Charles F.; O'Donnell, Christopher P. (2020-05-08). "A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning". The Journal of Biological Chemistry. 295 (19): 6357–6371. doi:10.1074/jbc.RA119.010593. ISSN 1083-351X. PMC 7212636. PMID 32205448.
  44. ↑ Rose, Jason J.; Wang, Ling; Xu, Qinzi; McTiernan, Charles F.; Shiva, Sruti; Tejero, Jesus; Gladwin, Mark T. (2017-03-01). "Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy". American Journal of Respiratory and Critical Care Medicine. 195 (5): 596–606. doi:10.1164/rccm.201606-1275CI. ISSN 1535-4970. PMC 5363978. PMID 27753502.
  45. ↑ "Our Team | Globin Solutions, Inc". Retrieved 2024-01-12.
  46. ↑ "Technology | Globin Solutions, Inc". Retrieved 2024-01-12.
  47. ↑ Rochon, Elizabeth R.; Xue, Jianmin; Mohammed, Manush Sayd; Smith, Caroline; Hay-Schmidt, Anders; DeMartino, Anthony W.; Clark, Adam; Xu, Qinzi; Lo, Cecilia W.; Tsang, Michael; Tejero, Jesus; Gladwin, Mark T.; Corti, Paola (14 December 2023). "Cytoglobin regulates NO-dependent cilia motility and organ laterality during development". Nature Communications. 14 (8333): 8333. Bibcode:2023NatCo..14.8333R. doi:10.1038/s41467-023-43544-0. PMC 10721929. PMID 38097556.
  48. ↑ Hopson, Jayne (2024-03-15). "Dr. Mark T. Gladwin Leads Global Charge Against Sickle Cell Disease". The Baltimore Times. Retrieved 2026-01-29.
  49. ↑ Gladwin, Mark T.; Sachdev, Vandana; Jison, Maria L.; Shizukuda, Yukitaka; Plehn, Jonathan F.; Minter, Karin; Brown, Bernice; Coles, Wynona A.; Nichols, James S.; Ernst, Inez; Hunter, Lori A.; Blackwelder, William C.; Schechter, Alan N.; Rodgers, Griffin P.; Castro, Oswaldo (2004-02-26). "Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease". New England Journal of Medicine. 350 (9): 886–895. doi:10.1056/NEJMoa035477. ISSN 0028-4793. PMID 14985486.
  50. ↑ Gladwin, Mark (4 December 2023). "Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)". ClinicalTrials.gov. Retrieved 3 January 2024.
  51. ↑ Cohn, Sarah True, Meredith (2024-01-12). "Maryland doctors are loosening sickle cell's painful grip on patients worldwide". The Baltimore Banner. Retrieved 2024-01-12.{{cite web}}: CS1 maint: multiple names: authors list (link)
  52. ↑ "American Thoracic Society | Assembly on Pulmonary Circulation…". American Thoracic Society. Retrieved 2026-04-20.
  53. ↑ Teich, Debby (2026-04-27). "Four Miller School Alumni Honored at 2026 Medical Alumni Awards". InventUM. Retrieved 2026-04-28.
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