Mannitol-1-phosphatase
| mannitol-1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.22 | ||||||||
| CAS no. | 9055-29-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme mannitol-1-phosphatase (EC 3.1.3.22) catalyzes the reaction
The enzyme characterised from Piricularia oryzae and celery hydrolyses D-mannitol 1-phosphate to mannitol and orthophosphate.[1][2][3] In algae, mannitol produced by this reaction can represent up to 25% of their dry weight.[4] The gene for this enzyme from Eimeria tenella has been overexpressed and used to increase mannitol production in Lactococcus lactis.[5][6]
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is D-mannitol-1-phosphate phosphohydrolase. This enzyme is also called mannitol-1-phosphate phosphatase.[7]
References
- ↑ Yamada H, Okamoto K, Kodama K, Noguchi F, Tanaka S (May 1961). "Enzymatic studies on mannitol formation by Piricularia oryzae". J. Biochem. 49. Tokyo: 404–410. doi:10.1093/oxfordjournals.jbchem.a127317. PMID 13787089.
- ↑ Rumpho ME, Edwards GE, Loescher WH (1983). "A Pathway for Photosynthetic Carbon Flow to Mannitol in Celery Leaves : Activity and Localization of Key Enzymes". Plant Physiol. 73 (4): 869–873. doi:10.1104/pp.73.4.869. PMC 1066569. PMID 16663332.
- ↑ Edmond, Vovener de Verlands; Hong, Zonglie; Nelson, Andrew S. (2025). "Sugar alcohols in plants: Implications for enhancing tree seedlings drought tolerance and production strategies". BMC Plant Biology. 25 (1) 891. doi:10.1186/s12870-025-06860-9. PMC 12239448. PMID 40634904.
- ↑ Tonon, Thierry; Li, Yi; McQueen-Mason, Simon (2017). "Mannitol biosynthesis in algae: More widespread and diverse than previously thought". New Phytologist. 213 (4): 1573–1579. doi:10.1111/nph.14358. PMID 27883223.
- ↑ Wisselink, H. Wouter; Moers, Antoine P. H. A.; Mars, Astrid E.; Hoefnagel, Marcel H. N.; De Vos, Willem M.; Hugenholtz, Jeroen (2005). "Overproduction of Heterologous Mannitol 1-Phosphatase: A Key Factor for Engineering Mannitol Production by Lactococcus lactis". Applied and Environmental Microbiology. 71 (3): 1507–1514. doi:10.1128/AEM.71.3.1507-1514.2005. PMC 1065179. PMID 15746354.
- ↑ Yan, D.; Cai, X.; Xue, H.; et al. (2024). "Recent advances in the bioproduction of mannitol". Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 40 (8): 2626–2643. doi:10.13345/j.cjb.240220. PMID 39174473.
- ↑ Enzyme 3.1.3.22 at KEGG Pathway Database.
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