Maleylpyruvate isomerase
| Maleylpyruvate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.2.1.4 | ||||||||
| CAS no. | 9023-77-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Maleylpyruvate isomerase (EC 5.2.1.4) is an enzyme that catalyzes the chemical reaction
The enzyme has one substrate, 3-maleylpyruvic acid, which it converts to its geometric isomer, 3-fumarylpyruvic acid.[1][2]
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 3-maleylpyruvate cis-trans-isomerase. This enzyme participates in tyrosine metabolism.[3]
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 2NSF and PDB: 2NSG.
References
- ↑ Enzyme 5.2.1.4 at KEGG Pathway Database.
- ↑ Lack L (November 1961). "Enzymic cis-trans isomerization of maleylpyruvic acid". The Journal of Biological Chemistry. 236 (11): 2835–40. doi:10.1016/S0021-9258(19)76386-8. PMID 14461395.
- ↑ Sugiyama, Shin-ich; Yano, Keiji; Komagata, Kazuo; Arima, Kei (1960). "Metabolism of Aromatic Compounds by Microbes". Bulletin of the Agricultural Chemical Society of Japan. 24 (3): 243–248. doi:10.1271/bbb1924.24.243.