Magnesium protoporphyrin IX methyltransferase
| Magnesium protoporphyrin IX methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Magnesium protoporphyrin IX O-methyltransferase homodimer, Synechocystis | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.1.11 | ||||||||
| CAS no. | 9029-82-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Magnesium protoporphyrin IX methyltransferase (EC 2.1.1.11) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which one of the two carboxylic acid groups in magnesium protoporphyrin is converted to a methyl ester. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).[1][2][3]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase. This enzyme is part of the biosynthetic pathway to chlorophylls.[4][5][6]
See also
References
- ↑ Ebbon JG, Tait GH (1969). "Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z". Biochem. J. 111 (4): 573–82. doi:10.1042/bj1110573. PMC 1187578. PMID 5774480.
- ↑ Bollivar DW, Jiang ZY, Bauer CE, Beale SI (1994). "Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase". J. Bacteriol. 176 (17): 5290–6. doi:10.1128/jb.176.17.5290-5296.1994. PMC 196713. PMID 8071204.
- ↑ Gibson LC, Hunter CN (1994). "The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methyltransferase". FEBS Lett. 352 (2): 127–30. Bibcode:1994FEBSL.352..127G. doi:10.1016/0014-5793(94)00934-1. PMID 7925960.
- ↑ Willows, Robert D. (2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (6): 327–341. doi:10.1039/B110549N. PMID 12828371.
- ↑ Bollivar, David W. (2007). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research. 90 (2): 173–194. doi:10.1007/s11120-006-9076-6. PMID 17370354.
- ↑ Shepherd M, Reid JD, Hunter CN (2003). "Purification and kinetic characterization of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803". Biochem. J. 371 (Pt 2): 351–60. doi:10.1042/BJ20021394. PMC 1223276. PMID 12489983.
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