MRN complex-interacting protein

MRNIP
Identifiers
Aliases	MRNIP, C5orf45, MRN complex interacting protein
External IDs	OMIM: 617154; MGI: 1915317; GeneCards: MRNIP
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.3 Start 179,835,133 bp End 179,862,173 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B1.3 Start 50,065,271 bp End 50,090,942 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right uterine tube pituitary gland anterior pituitary left ovary left lobe of thyroid gland right lobe of thyroid gland canal of the cervix right ovary Top expressed in blastocyst zygote secondary oocyte primary oocyte genital tubercle right kidney proximal tubule spermatocyte yolk sac morula More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding protein binding Cellular component nucleus nucleoplasm Mre11 complex Biological process DNA repair cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint signaling response to ionizing radiation positive regulation of protein kinase activity protein localization to chromatin positive regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51149 68067 Ensembl ENSG00000161010 ENSG00000283918 ENSMUSG00000020381 UniProt Q6NTE8 Q9D1F5 RefSeq (mRNA) NM_016175 NM_001017987 NM_001018061 NM_001018062 NM_026543 RefSeq (protein) NP_001017987 NP_057259 NP_080819 Location (UCSC) Chr 5: 179.84 – 179.86 Mb Chr 11: 50.07 – 50.09 Mb PubMed search
Wikidata
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MRN complex-interacting protein is a protein that in humans is encoded by the MRNIP gene (previously C5orf45). The MRNIP protein is involved with DNA repair through its interaction with the MRN complex.

Further reading

• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, et al. (March 2007). "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–315. doi:10.1016/j.ygeno.2006.11.012. PMC 4647941. PMID 17207965.