MIR124-3

MIR124-3
Identifiers
Aliases	MIR124-3, MIRN124-3, MIRN124A3, mir-124-3, microRNA 124-3
External IDs	GeneCards: MIR124-3
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 63,178,500 bp End 63,178,586 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood putamen body of pancreas tibial arteries body of stomach vagina dorsolateral prefrontal cortex Brodmann area 9 anterior cingulate cortex right auricle of heart n/a More reference expression data BioGPS n/a
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 406909 n/a Ensembl ENSG00000207598 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 20: 63.18 – 63.18 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J (May 2010). "miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma". Carcinogenesis. 31 (5): 766–76. doi:10.1093/carcin/bgp250. PMID 19843643.
• Hunt S, Jones AV, Hinsley EE, Whawell SA, Lambert DW (January 2011). "MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1". FEBS Lett. 585 (1): 187–92. doi:10.1016/j.febslet.2010.11.038. PMID 21112327. S2CID 21745477.
• Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D (December 2011). "CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer". Cancer Sci. 102 (12): 2126–31. doi:10.1111/j.1349-7006.2011.02101.x. PMID 21917081. S2CID 41681543.
• Gebauer K, Peters I, Dubrowinskaja N, Hennenlotter J, Abbas M, Scherer R, Tezval H, Merseburger AS, Stenzl A, Kuczyk MA, Serth J (January 2013). "Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma". Br. J. Cancer. 108 (1): 131–8. doi:10.1038/bjc.2012.537. PMC 3553529. PMID 23321515.
• Wang P, Chen L, Zhang J, Chen H, Fan J, Wang K, Luo J, Chen Z, Meng Z, Liu L (January 2014). "Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1". Oncogene. 33 (4): 514–24. doi:10.1038/onc.2012.598. PMID 23334332. S2CID 13273419.
• Xu X, Li S, Lin Y, Chen H, Hu Z, Mao Y, Xu X, Wu J, Zhu Y, Zheng X, Luo J, Xie L (November 2013). "MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1". J Transl Med. 11: 276. doi:10.1186/1479-5876-11-276. PMC 4228407. PMID 24180482.
• Ben Gacem R, Ben Abdelkrim O, Ziadi S, Ben Dhiab M, Trimeche M (May 2014). "Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease". Tumour Biol. 35 (5): 4047–56. doi:10.1007/s13277-013-1530-4. PMID 24375250. S2CID 14631322.
• Mi J, Chen D, Wu M, Wang W, Gao H (May 2014). "Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease". Mol Med Rep. 9 (5): 1839–43. doi:10.3892/mmr.2014.2022. PMID 24604230.
• Leung LY, Chan CP, Leung YK, Jiang HL, Abrigo JM, Wang de F, Chung JS, Rainer TH, Graham CA (June 2014). "Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke". Clin. Chim. Acta. 433: 139–44. doi:10.1016/j.cca.2014.03.007. PMID 24650689.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.