MINAR1

MINAR1
Identifiers
Aliases	MINAR1, membrane integral NOTCH2 associated receptor 1, KIAA1024, UBTOR
External IDs	OMIM: 618054; MGI: 2667167; GeneCards: MINAR1
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.1 Start 79,432,336 bp End 79,472,304 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.1 Start 89,469,269 bp End 89,505,178 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum endothelial cell testicle cerebellar vermis buccal mucosa cell Top expressed in habenula lumbar spinal ganglion substantia nigra medial vestibular nucleus mammillary body dorsal tegmental nucleus pontine nuclei ventral tegmental area facial motor nucleus lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane plasma membrane Biological process negative regulation of cell population proliferation negative regulation of angiogenesis angiogenesis negative regulation of neuron projection development negative regulation of cell growth negative regulation of protein ubiquitination negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 23251 209743 Ensembl ENSG00000169330 ENSMUSG00000039313 UniProt Q9UPX6 Q8K3V7 RefSeq (mRNA) NM_015206 NM_153509 RefSeq (protein) NP_056021 NP_705729 Location (UCSC) Chr 15: 79.43 – 79.47 Mb Chr 9: 89.47 – 89.51 Mb PubMed search
Wikidata
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Major intrinsically disordered Notch2-binding receptor 1 is a protein that in humans is encoded by the MINAR1 gene (previously KIAA1024). The MINAR1 protein regulates and inhibits mTOR signaling by stabilizing DEPTOR, an mTOR complex component. A notable homolog is MINAR2, which is sometimes called “major intrinsically disordered Notch2-binding receptor 1-like”.