Luteolin O-methyltransferase
| Luteolin O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.42 | ||||||||
| CAS no. | 37205-55-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Luteolin O-methyltransferase (EC 2.1.1.42) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the flavone, luteolin, is converted to chrysoeriol. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH).[1]
Luteolin O-methyltransferase can also act on flavanols and converts quercetin to isorhamnetin:[2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase. Other names in common use include o-dihydric phenol methyltransferase, luteolin methyltransferase, luteolin 3'-O-methyltransferase, o-diphenol m-O-methyltransferase, o-dihydric phenol meta-O-methyltransferase, and S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase.[3] This enzyme participates in flavonoid biosynthesis and reacts with flavones in the 3' position, preferring those with a second hydroxy group adjacent in the 4' position.[4][5]
References
- ↑ Ebel, Jürgen; Hahlbrock, Klaus; Grisebach, Hans (1972). "Purification and properties of an o-dihydricphenol meta-O-methyltransferase from cell suspension cultures of parsley and its relation to flavonoid biosynthesis". Biochimica et Biophysica Acta (BBA) - Enzymology. 268 (2): 313–326. doi:10.1016/0005-2744(72)90326-9. PMID 5026305.
- ↑ Muzac, Ingrid; Wang, Jing; Anzellotti, Dominique; Zhang, Hong; Ibrahim, Ragai K. (2000). "Functional Expression of an Arabidopsis cDNA Clone Encoding a Flavonol 3′-O-Methyltransferase and Characterization of the Gene Product". Archives of Biochemistry and Biophysics. 375 (2): 385–388. doi:10.1006/abbi.1999.1681. PMID 10700397.
- ↑ Enzyme 2.1.1.42 at KEGG Pathway Database.
- ↑ Kim, B.G.; Lee, H.J.; Park, Y.; Lim, Y.; Ahn, J.-H. (2006). "Characterization of an O-methyltransferase from soybean". Plant Physiology and Biochemistry. 44 (4): 236–241. doi:10.1016/j.plaphy.2006.05.003. PMID 16777424.
- ↑ Lee, Yoon Jung; Kim, Bong Gyu; Chong, Youhoon; Lim, Yoongho; Ahn, Joong-Hoon (2008). "Cation dependent O-methyltransferases from rice". Planta. 227 (3): 641–647. doi:10.1007/s00425-007-0646-4. PMID 17943312.