List of naturally occurring phenethylamines

Trichocereus macrogonus var. pachanoi, syn. Echinopsis pachanoi contain several phenethylamines.

Naturally occurring phenethylamines are organic compounds which may be thought of as being derived from phenethylamine itself that are found in living organisms.

Tyramine is a phenethylamine that occurs widely in plants[1] and animals, and is metabolized by various enzymes, including monoamine oxidases. Substituted phenethylamines like mescaline are found in psychoactive cactus, and perhaps in some Acacia or Senegalia species.[2]: 212–213 [3]

List of phenethylamines

Selected phenethylamines
Short Name Origin Rα R4 R5 RN1 RN2 Full Name
PhenethylamineNatural?????2-phenylethan-1-amine
HordenineNatural?????N,N-Dimethyltyramine[2]: 147–152 
LophophineNatural?????3-methoxy-4,5-methylenedioxyphenethylamine[2]: 154–155 
MescalineNatural?????3,4,5-trimethoxyphenethylamine[2]: 212–225 
DMPEANatural?????3,4-dimethoxyphenethylamine
TyramineNatural?????4-Hydroxyphenethylamine[2]: 310–312 
Natural?????3-hydroxy-4,5-dimethoxyphenethylamine
3-MTNatural?????4-hydroxy-3-methoxyphenethylamine
Natural?????4-hydroxy-3,5-dimethoxyphenethylamine

References

  1. ↑ T. A. Smith (1977) Phytochemistry 16 9-18.
  2. 1 2 3 4 5 Shulgin, Alexander T; Manning, Tania; Daley, Paul F (2011). The Shulgin Index. Berkeley: Transform Press. ISBN 978-0-9630096-3-0.
  3. ↑ "Acacias and Natural Amphetamine". Ask Dr. Shulgin Online. Center for Cognitive Liberty & Ethics. 2001-09-26. Archived from the original on 2002-12-27. Retrieved 2026-04-02.