List of adverse effects of valproate
List of adverse effects of valproate by frequency:[1][2][3][4]
Very common (>10%)
- Nausea
- Vomiting
- Diarrhea
- Headache
- Low platelet count (dose-related)
- Tremor (dose-related)
- Alopecia (hair loss, usually temporary)
- Drowsiness
- Dizziness
- Hyperandrogenism in females
- Seeing double
- Indigestion
- Lazy eye
- Infection
- Tinnitus
- Elevated aminotransferase concentrations (dose-related; indicative of liver injury)
Common (1-10%)
* Paresthesia
- Abdominal pain
- Tremor
- Increased appetite
- Weight gain
- Ataxia
- Polycystic ovaries
- Memory impairment
- Menstrual irregularities
- Rash
- Back pain
- Mood changes
- Anxiety
- Confusion
- Abnormal gait
- Hallucinations
- Catatonia
- Dysarthria
- Tardive dyskinesia
- Vertigo
- High blood levels of ammonia without symptoms
Uncommon (0.1-1%)
- Peripheral edema
- Syndrome of inappropriate secretion of antidiuretic hormone (SIAH)
Rare (<0.1% frequency)
* Liver failure
- Pancreatitis (these two usually occur in first 6 months and can be fatal)
- Leukopenia (low white blood cell count)
- Neutropenia (low neutrophil count)
- Pure red cell aplasia
- Agranulocytosis
- Extrapyramidal syndrome (including parkinsonism, may be reversible)
- Brain problems due to high ammonia levels
- Drug-induced hypothermia (low body temperature)
- Hypersensitivity reactions including multi-organ hypersensitivity syndrome
- Eosinophilic pleural effusion
- Bone fractures (reduced BMD with long-term use)
References
- ↑ "Depakene, Stavzor (valproic acid) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 February 2014.
- ↑ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
- ↑ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.
- ↑ "Valpro sodium valproate" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 16 December 2013. Retrieved 14 February 2014.
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