Leucine transaminase
| Leucine transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.6 | ||||||||
| CAS no. | 9030-37-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Leucine transaminase (EC 2.6.1.6) is an enzyme characterised from rat liver that catalyzes a reversible chemical reaction to interconvert L-leucine and α-ketoglutaric acid with α-ketoisocaproic acid and L-glutamic acid:[1][2]
The enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-leucine:2-oxoglutarate aminotransferase. Other names in common use include L-leucine aminotransferase, leucine 2-oxoglutarate transaminase, leucine aminotransferase, and leucine-alpha-ketoglutarate transaminase. It employs one cofactor, pyridoxal phosphate.[3]
References
- ↑ Aki K, Ogawa K, Ichihara A (1968). "Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver". Biochim. Biophys. Acta. 159 (2): 276–84. doi:10.1016/0005-2744(68)90076-4. PMID 4968655.
- ↑ Ikeda T, Konishi Y, Ichihara A (1976). "Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria". Biochim. Biophys. Acta. 445 (3): 622–31. doi:10.1016/0005-2744(76)90115-7. PMID 974100.
- ↑ Enzyme 2.6.1.6 at KEGG Pathway Database.