Limbic system-associated membrane protein

LSAMP
Identifiers
Aliases	LSAMP, IGLON3, LAMP, limbic system-associated membrane protein, limbic system associated membrane protein
External IDs	OMIM: 603241; MGI: 1261760; GeneCards: LSAMP
Gene location (Human)
Chr.	Chromosome 3 (human)
End	117,139,389 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	42,181,679 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; entorhinal cortex; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; ventral tegmental area; ; pons; ; pars compacta; ; superior vestibular nucleus; ; primary visual cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; facial motor nucleus; ; cerebellar cortex; ; hippocampus proper; ; superior frontal gyrus; ; primary visual cortex; ; anterior horn of spinal cord; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	anchored component of membrane; membrane; extracellular region; plasma membrane; cytosol; integral component of membrane;
Biological process	cell adhesion; nervous system development; locomotory exploration behavior;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4045
	268890
	ENSG00000185565
	ENSMUSG00000061080
	Q13449
	Q8BLK3
	NM_002338; NM_001318915
	NM_175548; NM_001347236
	NP_001305844; NP_002329
	NP_001334165; NP_001348210; NP_001348211
	Wikidata
View/Edit Human	View/Edit Mouse

Limbic system-associated membrane protein (shortened to LSAMP or LAMP) is a protein which in humans is encoded by the gene LSAMP.

Structure

LSAMP is a 64- to 68-kDa heavily glycosylated protein.

Tissue distribution

LSAMP is found in neurons, specifically it is distributed in cortical and subcortical regions of the limbic system.^[5]

Subcellular distribution

LSAMP protein is expressed on the surface of somata and proximal dendrites of neurons where it integrates via glycosyl-phosphatidyl-inositol (GPI) anchor.^[6] Despite the name, LSAMP is not expressed only in the limbic-associated areas, but also less intensely in the midbrain and hindbrain regions.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185565 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061080 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pimenta AF, Fischer I, Levitt P (May 1996). "cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)". Gene. 170 (2): 189–195. doi:10.1016/0378-1119(96)84698-1. PMID 8666243.
1 2 Innos J, Koido K, Philips MA, Vasar E (2013). "Limbic system associated membrane protein as a potential target for neuropsychiatric disorders". Frontiers in Pharmacology. 4 32. doi:10.3389/fphar.2013.00032. PMC 3607788. PMID 23532449.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185565 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Pimenta AF, Fischer I, Levitt P (May 1996). "cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)". Gene. 170 (2): 189–195. doi:10.1016/0378-1119(96)84698-1. PMID 8666243.

[Innos_2013-6] 1 2 Innos J, Koido K, Philips MA, Vasar E (2013). "Limbic system associated membrane protein as a potential target for neuropsychiatric disorders". Frontiers in Pharmacology. 4 32. doi:10.3389/fphar.2013.00032. PMC 3607788. PMID 23532449.

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