L-rhamnono-1,4-lactonase

L-rhamnono-1,4-lactonase
Identifiers
EC no.3.1.1.65
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme L-rhamnono-1,4-lactonase (EC 3.1.1.65) catalyzes the reaction

2D representation of the chemical structure of Q27102728.
L-rhamnono-1,4-lactone
 
H2O
 
Reversible left-right reaction arrow with minor forward substrate(s) from top left and minor reverse product(s) to bottom left
H2O
 
 
2D representation of the chemical structure of Q27102335.
L-rhamnonic acid

The enzyme characterised from Pullularia pullulans, Pichia stipitis and Debaryomyces polymorphus hydrolyses L-rhamnono-1,4-lactone to L-rhamnonic acid.[1][2][3] The enzyme belongs to the amidohydrolase superfamily and is a member of Cluster of Orthologous Groups (COG) 3618.[4]

Nomenclature

This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is L-rhamnono-1,4-lactone lactonohydrolase. Other names in common use include Lrhamno-γ-lactonase, L-rhamnono-γ-lactonase, and L-rhamnonate dehydratase.[5]

References

  1. ↑ Rigo, Liu Un; Marechal, L. R.; Vieira, Muriel M.; Veiga, L. A. (1985). "Oxidative pathway for L-rhamnose degradation in Pullularia pullulans". Canadian Journal of Microbiology. 31 (9): 817–822. doi:10.1139/m85-153.
  2. ↑ Twerdochlib, A. L.; Pedrosa, F. O.; Funayama, S.; Rigo, L. U. (1994). "L-Rhamnose metabolism in Pichia stipitis and Debaryomyces polymorphus". Canadian Journal of Microbiology. 40 (11): 896–902. doi:10.1139/m94-144.
  3. ↑ Schomburg, Dietmar; Stephan, Dörte (1998). "L-Rhamnono-1,4-lactonase". Enzyme Handbook 15. pp. 45–47. doi:10.1007/978-3-642-58948-5_11. ISBN 978-3-540-64116-2.
  4. ↑ Hobbs, Merlin Eric; Vetting, Matthew; Williams, Howard J.; et al. (2013). "Discovery of an l-Fucono-1,5-lactonase from cog3618 of the Amidohydrolase Superfamily". Biochemistry. 52 (1): 239–253. doi:10.1021/bi3015554. PMC 3542637. PMID 23214453.
  5. ↑ Enzyme 3.1.1.65 at KEGG Pathway Database.
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