L-arabinonolactonase
| L-arabinonolactonase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.15 | ||||||||
| CAS no. | 9025-95-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
L-arabinonolactonase (EC 3.1.1.15) is an enzyme that catalyzes the reaction
L-arabinono-1,4-lactone
H2O
L-arabinonic acid
The enzyme characterised from Pseudomonas saccharophila hydrolyses L-arabinono-1,4-lactone to give L-arabinonic acid. The reaction is part of a sequence that converts arabinose to α-ketoglutaric acid.[1][2] It has also been found in Rhizobium species.[3] A crystal structure has been determined.[4]
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is L-arabinono-1,4-lactone lactonohydrolase.[5]
References
- ↑ Weimberg, R.; Doudoroff, Michael (1955). "The oxidation of L-arabinose by Pseudomonas saccharophila". Journal of Biological Chemistry. 217 (2): 607–624. doi:10.1016/S0021-9258(18)65926-5. PMID 13271422.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "L-Arabinonolactonase". Enzyme Handbook 3. pp. 75–77. doi:10.1007/978-3-642-76463-9_13. ISBN 978-3-642-48962-4.
- ↑ Dilworth, M. J.; Arwas, R.; McKay, I. A.; Saroso, S.; Glenn, A. R. (1986). "Pentose Metabolism in Rhizobium leguminosarum MNF300 and in Cowpea Rhizobium NGR234". Microbiology. 132 (10): 2733–2742. doi:10.1099/00221287-132-10-2733.
- ↑ Watanabe, Seiya; Yoshiwara, Kentaroh; Matsubara, Ryo; Watanabe, Yasunori (2022). "Crystal structure of L-arabinose 1-dehydrogenase as a short-chain reductase/Dehydrogenase protein". Biochemical and Biophysical Research Communications. 604: 14–21. doi:10.1016/j.bbrc.2022.03.028. PMID 35279441.
- ↑ Enzyme 3.1.1.15 at KEGG Pathway Database.
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