Isoliquiritigenin 2'-O-methyltransferase
| Isoliquiritigenin 2'-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.154 | ||||||||
| CAS no. | 139317-14-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.154) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the chalcone, isoliquiritigenin, is converted to a specific methyl ether, 2'-O-methylisoliquiritigenin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from alfalfa.[1][2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.[3]
References
- ↑ Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.)". Arch. Biochem. Biophys. 293 (1): 158–66. doi:10.1016/0003-9861(92)90379-B. PMID 1731632.
- ↑ Ichimura M, Furuno T, Takahashi T, Dixon RA, Ayabe S (1997). "Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures". Phytochemistry. 44 (6): 991–5. doi:10.1016/S0031-9422(96)00670-X. PMID 9055445.
- ↑ Enzyme 2.1.1.154 at KEGG Pathway Database.