Iodophenol O-methyltransferase
| Iodophenol O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.26 | ||||||||
| CAS no. | 37256-95-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Iodophenol O-methyltransferase (EC 2.1.1.26) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which 2-iodophenol is converted to 2-iodoanisole. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH). Other iodophenols are also methylated, with the highest activity being found with 4-hydroxy-3,5-diiodobenzoic acid (ioxynic acid).[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-iodophenol O-methyltransferase.[2]
References
- ↑ Tomita K, Cha CJ, Lardy HA (1964). "Enzymic O-methylation of iodinated phenols and thyroid hormones". J. Biol. Chem. 239 (4): 1202–1207. doi:10.1016/S0021-9258(18)91412-2. PMID 14165927.
- ↑ Enzyme 2.1.1.26 at KEGG Pathway Database.
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