Inositol 1-methyltransferase
| Inositol 1-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.40 | ||||||||
| CAS no. | 37257-06-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Inositol 1-methyltransferase (EC 2.1.1.40) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which inositol is converted to (–)-bornesitol. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH).[1]
The enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase. Other names in common use include inositol D-1-methyltransferase, S-adenosylmethionine:myo-inositol 3-methyltransferase, myo-inositol 3-O-methyltransferase, inositol 3-O-methyltransferase (name based on 1L-numbering system, and not 1D-numbering), and S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase. It participates in inositol phosphate metabolism.[2]
See also
- Inositol 3-methyltransferase which converts inositol to the enantiomer, (+)-bornesitol
References
- ↑ Wagner I, Hofmann H, Hoffmann-Ostenhof O (1969). "[Biosynthesis of cyclitols. 23. A soluble enzyme from pea seedlings methylating myo-inositol to D-bornesitol]". Hoppe-Seyler's Z. Physiol. Chem. 350 (11): 1460–4. doi:10.1515/bchm2.1969.350.2.1460. PMID 5362620.
- ↑ Enzyme 2.1.1.40 at KEGG Pathway Database.