Inositol-polyphosphate 5-phosphatase
| Inositol-polyphosphate 5-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.56 | ||||||||
| CAS no. | 106283-14-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses two related reactions.
The first produces D-myo-inositol 1,3,4-trisphosphate from D-myo-inositol 1,3,4,5-tetrakisphosphate. The second produces D-myo-inositol 1,4-bisphosphate from D-myo-inositol 1,4,5-trisphosphate:
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In both cases, the 5-phosphate is removed and the byproduct is orthophosphate (Pi}.[1][2][3][4] Ten mammalian isoforms are known.[5][6] The enzyme is part of an extensive signalling network.[7]
Other names of this enzyme include type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase.[8]
References
- ↑ Downes CP, Mussat MC, Michell RH (April 1982). "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". The Biochemical Journal. 203 (1): 169–77. doi:10.1042/bj2030169. PMC 1158207. PMID 6285891.
- ↑ Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE (May 1989). "Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain". European Journal of Biochemistry. 181 (2): 317–22. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
- ↑ Woscholski, R.; Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". In Cockcroft, S. (ed.). Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
- ↑ Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C (May 1994). "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". The Biochemical Journal. 300 ( Pt 1) (Pt 1): 85–90. doi:10.1042/bj3000085. PMC 1138127. PMID 8198557.
- ↑ Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA (2009). "The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease". The Biochemical Journal. 419 ( Pt 1) (1): 29–49. doi:10.1042/BJ20081673. PMID 19272022.
- ↑ McGrath, Meagan J.; Davies, Elizabeth M.; Ooms, Lisa M.; Nanayakkara, Randini; Gurung, Rajendra; Jones, Emily I.; Mitchell, Christina A. (2025). "The power of five – inositol polyphosphate 5-phosphatase gene mutations at the intersection of development and disease". FEBS Letters 1873-3468.70247. doi:10.1002/1873-3468.70247. PMID 41406168.
- ↑ Kim, Seyun; Bhandari, Rashna; Brearley, Charles A.; Saiardi, Adolfo (2024). "The inositol phosphate signalling network in physiology and disease" (PDF). Trends in Biochemical Sciences. 49 (11): 969–985. doi:10.1016/j.tibs.2024.08.005. PMID 39317578.
- ↑ Enzyme 3.1.3.56 at KEGG Pathway Database.
External links
- Inositol-polyphosphate+5-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)