Inositol-1,4-bisphosphate 1-phosphatase
| inositol-1,4-bisphosphate 1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure 1inp | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.3.57 | ||||||||
| CAS no. | 111070-17-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction
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The enzyme characterised from brain hydrolyses D-myo-inositol (1,4)-bisphosphate to inositol 4-phosphate and orthophosphate.[1][2][3][4] It has been studied in relation to bipolar disorder.[5]
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase.[6]
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1INP and PDB: 1JP4.
References
- ↑ Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
- ↑ Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. doi:10.1016/S0021-9258(18)61629-1. PMID 3029066.
- ↑ Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. doi:10.1016/S0021-9258(18)47680-6. PMID 2824473.
- ↑ Schomburg, Dietmar; Stephan, Dörte (1998). "Inositol-1,4-bisphosphate 1-phosphatase". Enzyme Handbook 15. pp. 123–126. doi:10.1007/978-3-642-58948-5_28. ISBN 978-3-540-64116-2.
- ↑ Cantelmi, Tonino; Di Lorenzo, Cherubino (2023). "Myo-inositol could restore peripheral inositol depletion induced by treatments for psychiatric and neurological conditions". A Clinical Guide to Inositols. pp. 73–85. doi:10.1016/B978-0-323-91673-8.00003-0. ISBN 978-0-323-91673-8.
- ↑ Enzyme 3.1.3.57 at KEGG Pathway Database.
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