Indole-3-pyruvate monooxygenase
| Indole-3-pyruvate monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.168 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Indole-3-pyruvate monooxygenase (EC 1.14.13.168, YUC2 (gene), spi1 (gene)) is an enzyme with systematic name indole-3-pyruvate,NADPH:oxygen oxidoreductase (1-hydroxylating, decarboxylating).[1] This enzyme catalyses the following chemical reaction
The four substrates of this enzyme are indole-3-pyruvic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are indole-3-acetic acid, oxidised NADP+, water, and carbon dioxide.[2]
The starting material is produced from the amino acid, tryptophan, by action of the enzyme L-tryptophan—pyruvate aminotransferase. The product of the reaction is the main auxin plant hormone.[3]
References
- ↑ Mashiguchi, K.; Tanaka, K.; Sakai, T.; Sugawara, S.; Kawaide, H.; Natsume, M.; Hanada, A.; Yaeno, T.; Shirasu, K.; Yao, H.; McSteen, P.; Zhao, Y.; Hayashi, K.-i.; Kamiya, Y.; Kasahara, H. (8 November 2011). "The main auxin biosynthesis pathway in Arabidopsis". Proceedings of the National Academy of Sciences. 108 (45): 18512–18517. Bibcode:2011PNAS..10818512M. doi:10.1073/pnas.1108434108. PMC 3215075. PMID 22025724.
- ↑ Enzyme 1.14.13.168 at KEGG Pathway Database.
- ↑ Zhao Y (March 2012). "Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants". Molecular Plant. 5 (2): 334–8. doi:10.1093/mp/ssr104. PMC 3309920. PMID 22155950.
External links
- Indole-3-pyruvate+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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