IOLA KY405

IOLA KY405 is an uncultured human respiratory tract-associated bacterium identified by a genomic approach in 2021.[1]

The genome is AT-rich and very small.[1]

The bacterium was tentatively linked to atypical Canine Infectious Respiratory Disease Complex.[2] However, subsequent work ruled this out.[3][4]

References

  1. 1 2 Fukuda, Kazumasa; Yamasaki, Kei; Ogura, Yoshitoshi; Kawanami, Toshinori; Ikegami, Hiroaki; Noguchi, Shingo; Akata, Kentarou; Katsura, Keisuke; Yatera, Kazuhiro; Mukae, Hiroshi; Hayashi, Tetsuya; Taniguchi, Hatsumi (2021). "A human respiratory tract-associated bacterium with an extremely small genome". Communications Biology. 4 (1): 628. doi:10.1038/s42003-021-02162-6. PMC 8155191. PMID 34040152.
  2. ↑ "Respiratory Syndrome of Unknown Etiology in Dogs 2022-3 in New England: Diagnostic Investigation" (PDF). noviams.com. Archived (PDF) from the original on 2023-11-28. Retrieved 2025-11-27.
  3. ↑ Hasan, Mahamudul; Schirtzinger, Erin E.; Stancic, Steven; Affonso, Pedro; Lu, Andrea; Souza-Neto, Jayme A.; Klenda, Katherine L.; Ferreyra, Franco Matias; Noll, Lance W.; Hanzlicek, Gregg A.; Retallick, Jamie; Miller, Laura C. (2026). "A targeted PCR approach for the detection of IOLA in canine infectious respiratory disease samples during an atypical CIRD outbreak in winter 2023". Frontiers in Veterinary Science. 13 1849862. doi:10.3389/fvets.2026.1849862. PMC 13354092. PMID 42433691.
  4. ↑ Thieulent, Côme J.; Laverack, Melissa; Carossino, Mariano; Cronk, Brittany; Caserta, Leonardo Cardia; Diel, Diego G.; Balasuriya, Udeni B. R. (2025). "Detection of pathogens in dogs with respiratory disease during winter 2023–2024 using multiplex QPCR/RT-QPCR assays and next-generation sequencing". Frontiers in Veterinary Science. 12 1617147. doi:10.3389/fvets.2025.1617147. PMC 12402941. PMID 40905007.
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