(S)-3-Hydroxy-3-
methylglutaryl-CoA
Hydroxymethylglutaryl-CoA hydrolase
| Hydroxymethylglutaryl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.5 | ||||||||
| CAS no. | 9025-89-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) catalyzes the reaction
The enzyme characterised from liver hydrolyses (S)-3-Hydroxy-3-
methylglutaryl-CoA to coenzyme A and the acid, meglutol, which forms the thioester in the starting material. The reaction is part of leucine metabolism.[1][2]. The enzyme may be important in the regulation of cholesterol biosynthesis in mammals.[3]
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is S-(2-hydroxyacyl)glutathione hydrolase. Other names in common use include β-hydroxy-beta-methylglutaryl coenzyme A hydrolase, β-hydroxy-β-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.[4]
References
- ↑ Dekker, Eugene E.; Schlesinger, Milton J.; Coon, Minor J. (1958). "Β-Hydroxy-β-Methylglutaryl Coenzyme A Deacylase". Journal of Biological Chemistry. 233 (2): 434–438. doi:10.1016/S0021-9258(18)64779-9. PMID 13563516.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Hydroxymethylglutaryl-CoA hydrolase". Enzyme Handbook 3. pp. 245–247. doi:10.1007/978-3-642-76463-9_54. ISBN 978-3-642-48962-4.
- ↑ Sipat, Abdullah B.; Sabine, John R. (1981). "Β-Hydroxy-β-methylglutaryl coenzyme a hydrolase of rat liver". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 666 (1): 181–190. doi:10.1016/0005-2760(81)90104-1. PMID 6170340.
- ↑ Enzyme 3.1.2.5 at KEGG Pathway Database.
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