Hydroxybutyrate-dimer hydrolase

Hydroxybutyrate-dimer hydrolase
Identifiers
EC no.3.1.1.22
CAS no.37278-37-8
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hydroxybutyrate-dimer hydrolase (EC 3.1.1.22) is an enzyme that catalyzes the reaction

2D representation of the chemical structure of Q27102511.
(R)-3-((R)-3-hydroxybutanoyloxy)butanoic acid
 
H2O
 
Rightward reaction arrow with minor substrate(s) from top left
 
 
 
2
 
2D representation of the chemical structure of Q27075135.
(R)-3-hydroxybutyric acid

The enzyme characterised from Pseudomonas lemoignei hydrolyses a dimer of (R)-3-hydroxybutyric acid back to the monomer.[1] The gene for this enzyme has been cloned for sequencing.[2] The enzyme is also found in Zoogloea ramigera.[3]

This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is (R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase. The enzyme is also called D-(–)-3-hydroxybutyrate-dimer hydrolase.[4]

References

  1. ↑ Delafield, F.P.; Cooksey, Keith E.; Doudoroff, Michael (1965). "Β-Hydroxybutyric Dehydrogenase and Dimer Hydrolase of Pseudomonas lemoignei". Journal of Biological Chemistry. 240 (10): 4023–4028. doi:10.1016/S0021-9258(18)97145-0. PMID 4954074.
  2. ↑ Zhang, K.; Shiraki, M.; Saito, T. (1997). "Purification of an extracellular D-(-)-3-hydroxybutyrate oligomer hydrolase from Pseudomonas sp. Strain A1 and cloning and sequencing of its gene". Journal of Bacteriology. 179 (1): 72–77. doi:10.1128/jb.179.1.72-77.1997. PMC 178663. PMID 8981982.
  3. ↑ Tanaka, Yoshimasa; Saito, Terumi; Fukui, Tetsuya; Tanio, Tomoharu; Tomita, Kenkichi (1981). "Purification and Properties of D(−)-3-Hydroxybutyrate-Dimer Hydrolase from Zoogloea ramigera I-16-M". European Journal of Biochemistry. 118 (1): 177–182. doi:10.1111/j.1432-1033.1981.tb05502.x. PMID 7285912.
  4. ↑ Enzyme 3.1.1.22 at KEGG Pathway Database.
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