Homospermidine synthase (spermidine-specific)
| Homospermidine synthase (spermidine-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.45 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Homospermidine synthase (spermidine-specific) (EC 2.5.1.45) is an enzyme that catalyzes the chemical reaction that combines putrescine with spermidine to form sym-homospermidine and 1,3-propanediamine:
Unlike the enzyme homospermidine synthase found in bacteria, this protein from plants like Senecio vulgaris is not capable of using putrescine alone as substrate.[1][2][3]
The enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).[4]
References
- ↑ Ober D, Hartmann T (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14777–82. Bibcode:1999PNAS...9614777O. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
- ↑ Ober D, Harms R, Hartmann T (2000). "Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision". Phytochemistry. 55 (4): 311–316. Bibcode:2000PChem..55..305O. doi:10.1016/S0031-9422(00)00267-3. PMID 11117877.
- ↑ Krossa, Sebastian; Faust, Annette; Ober, Dietrich; Scheidig, Axel J. (2016). "Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase–an Essential Enzyme of the Polyamine Metabolism". Scientific Reports. 6 19501. doi:10.1038/srep19501. PMC 4725965. PMID 26776105.
- ↑ Enzyme 2.5.1.45 at KEGG Pathway Database.