Histidinol-phosphate transaminase
| Histidinol-phosphate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Histidinol-phosphate transaminase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.6.1.9 | ||||||||
| CAS no. | 9032-98-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the reversible chemical reaction
-2-oxopropyl_phosphate.svg.png)
The enzyme first characterised from Neurospora crassa converts 3-(imidazol-4-yl)-2-oxopropyl phosphate to L-histidinol phosphate (a precursor to the amino acid histidine) using L-glutamic acid as the source of the amino group that is transferred. It uses pyridoxal phosphate as a cofactor and has also been found in Salmonella typhimurium.[1][2]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidinol-phosphate:2-oxoglutarate aminotransferase. Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, imidazoleacetol phosphate transaminase, L-histidinol phosphate aminotransferase, histidine:imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. It participates in five metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and novobiocin biosynthesis.[3]
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1FG3, PDB: 1FG7, PDB: 1GEW, PDB: 1GEX, PDB: 1GEY, PDB: 1H1C, PDB: 1IJI, PDB: 1UU0, PDB: 1UU1, PDB: 1UU2, and PDB: 2F8J.
References
- ↑ Ames, Bruce N.; Horecker, B.L. (1956). "The Biosynthesis of Histidine: Imidazoleacetol Phosphate Transaminase". Journal of Biological Chemistry. 220: 113–128. doi:10.1016/S0021-9258(18)65337-2. PMID 13319331.
- ↑ Martin, Robert G.; Goldberger, Robert F. (1967). "Imidazolylacetolphosphate: L-Glutamate Aminotransferase". Journal of Biological Chemistry. 242 (6): 1168–1174. doi:10.1016/S0021-9258(18)96159-4.
- ↑ Enzyme 2.6.1.9 at KEGG Pathway Database.