Histidinol-phosphatase
| Histidinol-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Histidinol-phosphatase tetramer, Thermus thermophilus | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.3.15 | ||||||||
| CAS no. | 9025-79-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme histidinol-phosphatase (EC 3.1.3.15) catalyzes the reaction
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The enzyme characterised from Neurospora crassa hydrolyses L-histidinol phosphate to histidinol and orthophosphate. The reaction is part of the biosynthesis of the amino acid histidine.[1][2][3]
Nomenclature
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.[4]
E. coli
In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.[5]
References
- ↑ Ames, Bruce N. (1957). "The biosynthesis of histidine; L-histidinol phosphate phosphatase". Journal of Biological Chemistry. 226 (2): 583–593. doi:10.1016/S0021-9258(18)70840-5. PMID 13438843.
- ↑ Ghodge, Swapnil V.; Fedorov, Alexander A.; Fedorov, Elena V.; Hillerich, Brandan; Seidel, Ronald; Almo, Steven C.; Raushel, Frank M. (2013). "Structural and Mechanistic Characterization of l-Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins". Biochemistry. 52 (6): 1101–1112. doi:10.1021/bi301496p. PMC 3570733. PMID 23327428.
- ↑ Kinateder, Thomas; Mayer, Carina; Nazet, Julian; Sterner, Reinhard (2024). "Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases". Protein Science. 33 (2) e4899. doi:10.1002/pro.4899. PMC 10804674. PMID 38284491.
- ↑ Enzyme 3.1.3.15 at KEGG Pathway Database.
- ↑ Brilli M, Fani R (February 2004). "Molecular evolution of hisB genes". Journal of Molecular Evolution. 58 (2): 225–237. Bibcode:2004JMolE..58..225B. doi:10.1007/s00239-003-2547-x. PMID 15042344. S2CID 1684458.
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