HGS (gene)

HGS
Identifiers
Aliases	HGS, HRS, hepatocyte growth factor-regulated tyrosine kinase substrate
External IDs	OMIM: 604375; MGI: 104681; GeneCards: HGS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,703,138 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,374,805 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; granulocyte; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; anterior pituitary; ; canal of the cervix; ; skin of abdomen; ; mucosa of transverse colon;
	Top expressed in
	Ileal epithelium; ; entorhinal cortex; ; perirhinal cortex; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; CA3 field; ; seminiferous tubule; ; spermatid; ; granulocyte; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; metal ion binding; protein binding; ubiquitin-like protein ligase binding;
Cellular component	endosome; early endosome membrane; multivesicular body membrane; intracellular membrane-bounded organelle; membrane; early endosome; extracellular exosome; cytoplasm; lysosome; cytosol; ESCRT-0 complex;
Biological process	protein localization to membrane; protein targeting to lysosome; negative regulation of epidermal growth factor receptor signaling pathway; membrane invagination; multivesicular body assembly; endosomal transport; positive regulation of gene expression; regulation of protein catabolic process; protein transport; regulation of MAP kinase activity; positive regulation of exosomal secretion; intracellular protein transport; signal transduction; negative regulation of cell population proliferation; negative regulation of receptor signaling pathway via JAK-STAT; macroautophagy; protein deubiquitination; membrane organization; transport; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9146
	15239
	ENSG00000185359
	ENSMUSG00000025793
	O14964
	Q99LI8
	NM_004712
	NM_001159328; NM_008244
	NP_004703
	NP_001152800; NP_032270
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.^[5]^[6]^[7]

Interactions

HGS has been shown to interact with:

CLTC^[8]
DLG4,^[9]
EPS15,^[10]^[11]
IL2RB,^[12]
Merlin,^[13]^[14]
STAM2,^[10]^[15]
Signal transducing adaptor molecule^[5]^[10]^[15]
TSG101.^[15]^[16]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185359 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025793 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, et al. (December 1997). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". The Journal of Biological Chemistry. 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. PMID 9407053.
↑ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–132. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
↑ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".
↑ Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". The EMBO Journal. 20 (17): 5008–5021. doi:10.1093/emboj/20.17.5008. PMC 125612. PMID 11532964.
↑ Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". The Journal of Neuroscience. 22 (15): 6415–6425. doi:10.1523/JNEUROSCI.22-15-06415.2002. PMC 6758133. PMID 12151521.
1 2 3 Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–12521. doi:10.1074/jbc.M210843200. PMID 12551915.
↑ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". The Journal of Biological Chemistry. 275 (20): 15271–15278. doi:10.1074/jbc.275.20.15271. PMID 10809762.
↑ Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, et al. (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". Journal of Cell Science. 121 (Pt 10): 1727–1738. doi:10.1242/jcs.024455. PMID 18445679.
↑ Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Human Molecular Genetics. 10 (8): 825–834. doi:10.1093/hmg/10.8.825. PMID 11285248.
↑ Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Human Molecular Genetics. 9 (11): 1567–1574. doi:10.1093/hmg/9.11.1567. PMID 10861283.
1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
↑ Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proceedings of the National Academy of Sciences of the United States of America. 100 (13): 7626–7631. Bibcode:2003PNAS..100.7626L. doi:10.1073/pnas.0932599100. PMC 164637. PMID 12802020.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)

Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". Exs. 65: 131–165. PMID 8380735.
Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes". The Journal of Biological Chemistry. 272 (33): 20538–20544. doi:10.1074/jbc.272.33.20538. PMID 9252367.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". The Journal of Biological Chemistry. 274 (42): 30080–30086. doi:10.1074/jbc.274.42.30080. PMID 10514494.
Kwong J, Roundabush FL, Hutton Moore P, Montague M, Oldham W, Li Y, et al. (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis". Journal of Cell Science. 113 (12): 2273–2284. doi:10.1242/jcs.113.12.2273. PMID 10825299.
Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, et al. (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". The EMBO Journal. 19 (17): 4577–4588. doi:10.1093/emboj/19.17.4577. PMC 302054. PMID 10970851.
Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, et al. (2000). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA". Molecular and Cellular Biology. 20 (24): 9346–9355. doi:10.1128/MCB.20.24.9346-9355.2000. PMC 102191. PMID 11094085.
Chin LS, Raynor MC, Wei X, Chen HQ, Li L (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". The Journal of Biological Chemistry. 276 (10): 7069–7078. doi:10.1074/jbc.M004129200. PMID 11110793.
Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1". The Journal of Biological Chemistry. 276 (32): 29943–29952. doi:10.1074/jbc.M104230200. PMID 11397816.
Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, et al. (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". Journal of Cell Science. 114 (Pt 12): 2255–2263. doi:10.1242/jcs.114.12.2255. PMID 11493665.
Steen H, Kuster B, Fernandez M, Pandey A, Mann M (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". The Journal of Biological Chemistry. 277 (2): 1031–1039. doi:10.1074/jbc.M109992200. PMID 11687594.
Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates". The Journal of Cell Biology. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266. PMID 11916981.
Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1). Cambridge, Mass.: 56–64. doi:10.1007/BF03402003. PMC 2039936. PMID 11984006.
Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking". The Journal of Biological Chemistry. 277 (31): 28212–28221. doi:10.1074/jbc.M111612200. PMID 12021262.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185359 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025793 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Asao_1997-5] 1 2 Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, et al. (December 1997). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". The Journal of Biological Chemistry. 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. PMID 9407053.

[Lu_1998-6] Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–132. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.

[entrez-7] "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".

[Raiborg_2001-8] Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". The EMBO Journal. 20 (17): 5008–5021. doi:10.1093/emboj/20.17.5008. PMC 125612. PMID 11532964.

[Chetkovich_2002-9] Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". The Journal of Neuroscience. 22 (15): 6415–6425. doi:10.1523/JNEUROSCI.22-15-06415.2002. PMC 6758133. PMID 12151521.

[Bache_2003-10] 1 2 3 Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–12521. doi:10.1074/jbc.M210843200. PMID 12551915.

[Bean_2000-11] Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". The Journal of Biological Chemistry. 275 (20): 15271–15278. doi:10.1074/jbc.275.20.15271. PMID 10809762.

[Yamashita_2008-12] Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, et al. (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". Journal of Cell Science. 121 (Pt 10): 1727–1738. doi:10.1242/jcs.024455. PMID 18445679.

[Gutmann_2001-13] Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Human Molecular Genetics. 10 (8): 825–834. doi:10.1093/hmg/10.8.825. PMID 11285248.

[Scoles_2000-14] Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Human Molecular Genetics. 9 (11): 1567–1574. doi:10.1093/hmg/9.11.1567. PMID 10861283.

[Rual_2005-15] 1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[Lu_2003-16] Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proceedings of the National Academy of Sciences of the United States of America. 100 (13): 7626–7631. Bibcode:2003PNAS..100.7626L. doi:10.1073/pnas.0932599100. PMC 164637. PMID 12802020.

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Interactions

References

External links

Further reading