HERC5

HERC5
Identifiers
Aliases	HERC5, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5
External IDs	OMIM: 608242; GeneCards: HERC5
Gene location (Human)
Chr.	Chromosome 4 (human)
End	88,506,163 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; sperm; ; left testis; ; germinal epithelium; ; monocyte; ; palpebral conjunctiva; ; body of uterus; ; left ovary;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ISG15 transferase activity; protein binding; transferase activity; RNA binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	perinuclear region of cytoplasm; cytosol; cytoplasm;
Biological process	ISG15-protein conjugation; negative regulation of type I interferon production; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of defense response to virus; defense response to virus; immune system process; protein polyubiquitination; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51191
	n/a
	ENSG00000138646
	n/a
	Q9UII4
	n/a
	NM_016323
	n/a
	NP_057407
	n/a
	Wikidata
View/Edit Human

E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.^[3]^[4]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.^[4] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.^[5]^[6]^[7]

Interactions

HERC5 has been shown to interact with NME2^[8] and Cyclin E1.^[3]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138646 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
1 2 "Entrez Gene: HERC5 hect domain and RLD 5".
↑ Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology. 8: 95. doi:10.1186/1742-4690-8-95. PMC 3228677. PMID 22093708.
↑ Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol. 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.
↑ Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMC 2887317. PMID 20542004.
↑ Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13). Switzerland: 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMC 11131906. PMID 18535780. S2CID 6897759.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138646 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10581175-3] 1 2 Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.

[entrez-4] 1 2 "Entrez Gene: HERC5 hect domain and RLD 5".

[pmid22093708-5] Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology. 8: 95. doi:10.1186/1742-4690-8-95. PMC 3228677. PMID 22093708.

[pmid_20385878-6] Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol. 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.

[pmid_20542004-7] Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMC 2887317. PMID 20542004.

[pmid18535780-8] Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13). Switzerland: 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMC 11131906. PMID 18535780. S2CID 6897759.

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