HELZ2

HELZ2
Identifiers
Aliases	HELZ2, PDIP-1, PRIC285, helicase with zinc finger 2
External IDs	OMIM: 611265; MGI: 2385169; GeneCards: HELZ2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,574,239 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,883,820 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; bone marrow cell; ; blood; ; sural nerve; ; appendix; ; monocyte; ; stromal cell of endometrium; ; spleen; ; apex of heart; ; upper lobe of left lung;
	Top expressed in
	lymph node; ; epithelium of small intestine; ; mesenteric lymph nodes; ; spleen; ; submandibular gland; ; left lobe of liver; ; blood; ; Paneth cell; ; subcutaneous adipose tissue; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; protein binding; ATP binding; hydrolase activity; helicase activity; nuclear receptor coactivator activity; metal ion binding; RNA binding; ribonuclease activity;
Cellular component	membrane; nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of lipid metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	85441
	229003
	ENSG00000130589
	ENSMUSG00000027580
	Q9BYK8
	E9QAM5
	NM_001037335; NM_033405
	NM_183162
	NP_001032412; NP_208384
	NP_898985
	Wikidata
View/Edit Human	View/Edit Mouse

Helicase with zinc finger 2 is a protein that in humans is encoded by the gene HELZ2 (previously PRIC285).^[5]

The protein encoded by this gene is a nuclear transcriptional co-activator for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARA). The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130589 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027580 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130589 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027580 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

[1]

[2]

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[4]

[5]

References

Further reading