Glycine formimidoyltransferase
| Glycine formimidoyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.2.4 | ||||||||
| CAS no. | 9029-84-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Glycine formimidoyltransferase (EC 2.1.2.4) is an enzyme that catalyzes the chemical reaction
This tetrahydrofolate–dependent enzyme catalyzes a nucleophilic acyl substitution of the formimino group from the cofactor 5-formiminotetrahydrofolate to glycine, giving N-formimidoylglycine, with tetrahydrofolate (THF) as a byproduct.[1] The enzyme can act in reverse to produce 5-formiminotetrahydrofolate.[2][3]
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism.[4]
References
- ↑ Sagers RD, Beck JV, Gruber W, Gunsalus IC (1956). "A tetrahydrofolic acid linked formimino transfer enzyme". J. Am. Chem. Soc. 78 (3): 694–695. Bibcode:1956JAChS..78..694G. doi:10.1021/ja01584a054.
- ↑ Rabinowitz JC; Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78 (21): 5702–5704. Bibcode:1956JAChS..78.5702R. doi:10.1021/ja01602a073.
- ↑ Rabinowitz JC; Pricer WE (1957). "Formation, isolation and properties of 5-formiminotetrahydrofolic acid". Fed. Proc. 16: 236.
- ↑ Enzyme 2.1.2.4 at KEGG Pathway Database.