GRAM domain-containing 2B

GRAMD2B
Identifiers
Aliases	GRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDs	MGI: 1914815; GeneCards: GRAMD2B
Gene location (Human)
Chr.	Chromosome 5 (human)
End	126,496,494 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	56,636,864 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; corpus callosum; ; external globus pallidus; ; bronchial epithelial cell; ; decidua; ; dorsal motor nucleus of vagus nerve; ; jejunal mucosa; ; Epithelium of choroid plexus; ; caudate nucleus;
	Top expressed in
	mucous cell of stomach; ; jejunum; ; islet of Langerhans; ; pyloric antrum; ; duodenum; ; epithelium of stomach; ; parotid gland; ; external carotid artery; ; internal carotid artery; ; left lobe of liver;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	65983
	107022
	ENSG00000155324
	ENSMUSG00000001700
	Q96HH9
	Q6PEM6
NM_001146319; NM_001146320; NM_001146321; NM_001146322; NM_023927;
	NM_001349541; NM_001349542; NM_001349543; NM_001349544
	NM_026240; NM_001360917
NP_001139791; NP_001139792; NP_001139793; NP_001139794; NP_076416;
	NP_001336470; NP_001336471; NP_001336472; NP_001336473
	NP_080516; NP_001347846
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2, is a protein encoded by the GRAMD2B gene.^[5]^[6]

GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.^[7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.^[8]^[7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
↑ "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
1 2 Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7) e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
↑ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.

[6] "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.

[pmid29469807-7] 1 2 Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7) e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.

[8] "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.

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