GATC-1021

GATC-1021
Clinical data
Other namesGATC1021; 8-Fluoroibogainalog
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC code
  • None
Identifiers
  • 8-fluoro-9-methoxy-3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole
Chemical and physical data
FormulaC14H17FN2O
Molar mass248.301 g·mol−1
3D model (JSmol)
  • CN1CCC(C2=CC(OC)=C(F)C=C2N3)=C3CC1
  • InChI=1S/C14H17FN2O/c1-17-5-3-9-10-7-14(18-2)11(15)8-13(10)16-12(9)4-6-17/h7-8,16H,3-6H2,1-2H3
  • Key:FKRSGPOSZOGYMZ-UHFFFAOYSA-N

GATC-1021, also known as 8-fluoroibogainalog, is a serotonin receptor modulator of the ibogalog family related to ibogainalog.[1] It is the 8-fluoro derivative of ibogainalog.[1]

The drug is known to act as a partial agonist of the serotonin 5-HT2A and 5-HT6 receptors (EmaxTooltip maximal efficacy = 56% and 27%, respectively), whereas it is inactive as an agonist of the serotonin 5-HT2B and 5-HT7 receptors.[1] It does not affect locomotor activity and does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[1] On the other hand, GATC-1021 has been found to reduce fentanyl self-administration in rodents.[1] The drug produces psychoplastogenic effects in rodents.[1] It crosses the blood–brain barrier in rodents.[1]

The chemical synthesis of GATC-1021 has been described.[1]

GATC-1021 was first described in the scientific literature by Valeria Lallai and colleagues in 2026.[1] There is interest in GATC-1021 for the potential treatment of opioid use disorder and for other indications such as treatment of schizophrenia.[1]

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 Lallai V, Kho S, Martin AC, Fowler JP, Roach ML, Wang K, et al. (April 2026). "AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder". Proceedings of the National Academy of Sciences of the United States of America. 123 (15) e2516807123. doi:10.1073/pnas.2516807123. PMID 41941629.
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