GAL3ST1

GAL3ST1
Identifiers
Aliases	GAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDs	OMIM: 602300; MGI: 1858277; GeneCards: GAL3ST1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,574,665 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,949,326 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; tibial nerve; ; gonad; ; putamen; ; duodenum; ; nucleus accumbens; ; amygdala; ; caudate nucleus; ; substantia nigra; ; sural nerve;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; right kidney; ; duodenum; ; lumbar subsegment of spinal cord; ; anterior horn of spinal cord; ; deep cerebellar nuclei; ; sciatic nerve; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; galactosylceramide sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane;
Biological process	glycolipid biosynthetic process; myelination; galactosylceramide biosynthetic process; protein N-linked glycosylation; spermatogenesis; sphingolipid metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9514
	53897
	ENSG00000128242
	ENSMUSG00000049721
	Q99999
	Q9JHE4
NM_004861; NM_001318103; NM_001318104; NM_001318105; NM_001318106;
	NM_001318107; NM_001318108; NM_001318109; NM_001318110; NM_001318111; NM_001318112; NM_001318113; NM_001318114; NM_001318115; NM_001318116
	NM_001177691; NM_001177703; NM_016922; NM_001382290; NM_001382291
NP_001305032; NP_001305033; NP_001305034; NP_001305035; NP_001305036;
	NP_001305037; NP_001305038; NP_001305039; NP_001305040; NP_001305041; NP_001305042; NP_001305043; NP_001305044; NP_001305045; NP_004852
	NP_001171162; NP_001171174; NP_058618; NP_001369219; NP_001369220
	Wikidata
View/Edit Human	View/Edit Mouse

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[5]^[6]^[7]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
↑ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (April 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". The Journal of Biological Chemistry. 272 (8): 4864–4868. doi:10.1074/jbc.272.8.4864. PMID 9030544.
1 2 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Siegrist HP, Jutzi H, Steck AJ, Burkart T, Wiesmann U, Herschkowitz N (October 1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochimica et Biophysica Acta. 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, et al. (January 1989). "Cloning and expression of human arylsulfatase A". The Journal of Biological Chemistry. 264 (2): 1252–1259. doi:10.1016/S0021-9258(19)85079-2. PMID 2562955.
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochemical and Biophysical Research Communications. 52 (3): 951–958. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". The Journal of Biological Chemistry. 246 (15): 4694–4702. doi:10.1016/S0021-9258(18)61991-X. PMID 5562350.
Costantino-Ceccarini E, Waehneldt TV, Ginalski H, Burgisser P, Reigner J, Matthieu JM (January 1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochemical Research. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086. S2CID 32069166.
Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". Journal of Neurochemistry. 38 (1): 233–241. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451. S2CID 23693243.
Honke K, Yamane M, Ishii A, Kobayashi T, Makita A (March 1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". Journal of Biochemistry. 119 (3): 421–427. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
Tsuda M, Egashira M, Niikawa N, Wada Y, Honke K (May 2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". European Journal of Biochemistry. 267 (9): 2672–2679. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". The Biochemical Journal. 368 (Pt 1): 317–324. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Sanger_1998-5] Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.

[Honke_1997-6] Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (April 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". The Journal of Biological Chemistry. 272 (8): 4864–4868. doi:10.1074/jbc.272.8.4864. PMID 9030544.

[entrez-7] 1 2 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

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[3]

[4]

[5]

[6]

[7]

References

Further reading