Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.[5][6][7]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]
G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules.[9]
Interactions
G3BP1 has been shown to interact with USP10.[10]
It also interacts with SND1[5].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, et al. (July 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Molecular and Cellular Biology. 16 (6): 2561–2569. doi:10.1128/MCB.16.6.2561. PMC 231246. PMID 8649363.
- ↑ Costa M, Ochem A, Staub A, Falaschi A (March 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Research. 27 (3): 817–821. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
- 1 2 "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
- ↑ Annibaldi A, Dousse A, Martin S, Tazi J, Widmann C (2011). "Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLOS ONE. 6 (12) e29024. Bibcode:2011PLoSO...629024A. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
- ↑ Mahboubi H, Stochaj U (April 2017). "Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease". Biochimica et Biophysica Acta. Molecular Basis of Disease. 1863 (4): 884–895. doi:10.1016/j.bbadis.2016.12.022. PMID 28095315.
- ↑ Soncini C, Berdo I, Draetta G (June 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29): 3869–3879. doi:10.1038/sj.onc.1204553. PMID 11439350.
Further reading
- Irvine K, Stirling R, Hume D, Kennedy D (2005). "Rasputin, more promiscuous than ever: a review of G3BP". The International Journal of Developmental Biology. 48 (10): 1065–1077. doi:10.1387/ijdb.041893ki. PMID 15602692.
- Onno M, Nakamura T, Hillova J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes". Oncogene. 7 (12): 2519–2523. PMID 1461655.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Gallouzi IE, Parker F, Chebli K, Maurier F, Labourier E, Barlat I, et al. (July 1998). "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability". Molecular and Cellular Biology. 18 (7): 3956–3965. doi:10.1128/MCB.18.7.3956. PMC 108980. PMID 9632780.
- Kociok N, Esser P, Unfried K, Parker F, Schraermeyer U, Grisanti S, et al. (August 1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". Journal of Cellular Biochemistry. 74 (2): 194–201. doi:10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M. PMID 10404389. S2CID 8259980.
- Tourrière H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, et al. (November 2001). "RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization". Molecular and Cellular Biology. 21 (22): 7747–7760. doi:10.1128/MCB.21.22.7747-7760.2001. PMC 99945. PMID 11604510.
- Barnes CJ, Li F, Mandal M, Yang Z, Sahin AA, Kumar R (March 2002). "Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors". Cancer Research. 62 (5): 1251–1255. PMID 11888885.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–2772. doi:10.1021/ac035352d. PMID 15144186.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Katsafanas GC, Moss B (2005). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". The Journal of Biological Chemistry. 279 (50): 52210–52217. doi:10.1074/jbc.M411033200. PMID 15471883.
- Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–126. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
- Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, et al. (August 2010). "Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions". FEBS Letters. 584 (16): 3525–3532. doi:10.1016/j.febslet.2010.07.022. PMC 7127458. PMID 20643132.
